HitPredict

Interactor 1: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Interactor 2: LMNB1 (P20700)
Lamin-B1
Gene: LMNB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.643

Property	Details
Experiments	26618866, 29924966, 31324722
Identification Methods	affinity chromatography technology, pull down, cross-linking study, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0016020 - membrane
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1480 Hs			1 586
+	Hs
		359458 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C6A_HUMAN (4-407): 1.22e-124: 380: 22.82
+	Hs
		528450 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C5_HUMAN (4-391): 3.18e-123: 377: 23.74
+	Hs
		528760 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C6C_HUMAN (4-407): 3.4e-87: 283: 22.09
+	Hs
		380440 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C6B_HUMAN (4-407): 8.91e-87: 282: 21.85
+	Hs
		529130 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C72_HUMAN (2-391): 2.63e-68: 231: 21.11
+	Hs
		359614 CFTR_HUMAN (1-1480): 0: 1031: 100.00		LMNA_HUMAN (3-550): 3.87e-63: 221: 55.37
+	Hs
		529006 CFTR_HUMAN (1-1480): 0: 1031: 100.00		LMNB2_HUMAN (20-586): 5.03e-61: 215: 56.22
+	Hs
		529780 CFTR_HUMAN (1-1480): 0: 1031: 100.00		KRT84_HUMAN (60-390): 5.25e-59: 208: 20.24
+	Hs
		529119 CFTR_HUMAN (1-1480): 0: 1031: 100.00		KRT81_HUMAN (54-390): 2.82e-51: 185: 20.48
+	Hs
		318772 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C75_HUMAN (4-391): 1.8e-50: 184: 20.61
+	Hs
		213928 CFTR_HUMAN (1-1480): 0: 1031: 100.00		KRT86_HUMAN (54-390): 4.46e-50: 181: 20.48
+	Hs
		528963 CFTR_HUMAN (1-1480): 0: 1031: 100.00		KRT85_HUMAN (54-390): 2.42e-49: 180: 20.35
+	Hs
		443292 CFTR_HUMAN (1-1480): 0: 1031: 100.00		VIME_HUMAN (28-390): 5.22e-30: 125: 28.65
+	Hs
		528496 CFTR_HUMAN (1-1480): 0: 1031: 100.00		DESM_HUMAN (28-390): 1.04e-28: 121: 31.13
+	Hs
		443691 ABCAA_HUMAN (46-1480): 1.11e-146: 489: 12.74		VIME_HUMAN (28-390): 5.22e-30: 125: 28.65
+	Hs
		360117 ABCA9_HUMAN (75-736): 2.05e-40: 166: 9.96		LMNA_HUMAN (3-550): 3.87e-63: 221: 55.37