HitPredict

Interactor 1: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Interactor 2: SFPQ (P23246)
Splicing factor, proline- and glutamine-rich (100 kDa DNA-pairing protein) (hPOMp100) (DNA-binding p52/p100 complex, 100 kDa subunit) (Polypyrimidine tract-binding protein-associated-splicing factor) (PSF) (PTB-associated-splicing factor)
Gene: SFPQ

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	31324722, 29924966
Identification Methods	affinity chromatography technology, pull down, cross-linking study
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1480 Hs			1 707
+	Hs
		529069 CFTR_HUMAN (1-1480): 0: 1031: 100.00		PABP4_HUMAN (287-694): 8.34e-83: 277: 17.38
+	Hs
		529208 CFTR_HUMAN (1-1480): 0: 1031: 100.00		PAP1L_HUMAN (287-675): 3.88e-71: 244: 16.33
+	Hs
		516343 CFTR_HUMAN (1-1480): 0: 1031: 100.00		PABP1_HUMAN (287-700): 1.59e-70: 243: 16.46
+	Hs
		529148 CFTR_HUMAN (1-1480): 0: 1031: 100.00		NONO_HUMAN (265-707): 1.49e-70: 239: 56.98
+	Hs
		529709 CFTR_HUMAN (1-1480): 0: 1031: 100.00		PABP3_HUMAN (287-700): 9.1e-69: 239: 16.88
+	Hs
		529541 CFTR_HUMAN (1-1480): 0: 1031: 100.00		PABP5_HUMAN (244-545): 3.2e-43: 162: 15.34
+	Sc
		376791 YCFI_YEAST (748-1433): 4.8e-56: 216: 14.59		PABP_YEAST (293-687): 2.32e-69: 239: 15.84