HitPredict

Interactor 1: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Interactor 2: DNJB2 (P25686)
DnaJ homolog subfamily B member 2 (Heat shock 40 kDa protein 3) (Heat shock protein J1) (HSJ-1)
Gene: DNAJB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	26618866, 31324722
Identification Methods	affinity chromatography technology, cross-linking study, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005789 - endoplasmic reticulum membrane GO:0005829 - cytosol GO:0051087 - protein-folding chaperone binding
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 1480 Hs			1 324
+	Hs
		257902 CFTR_HUMAN (1-1480): 0: 1031: 100.00		DNJB6_HUMAN (1-283): 7.47e-82: 252: 47.63
+	Hs
		529849 CFTR_HUMAN (1-1480): 0: 1031: 100.00		DJB11_HUMAN (2-228): 1.38e-51: 175: 27.31
+	Hs
		279273 CFTR_HUMAN (1-1480): 0: 1031: 100.00		DNJB5_HUMAN (2-239): 5.52e-44: 155: 25.88
+	Hs
		528576 CFTR_HUMAN (1-1480): 0: 1031: 100.00		DNJB1_HUMAN (2-161): 3.26e-43: 153: 40.63
+	Hs
		529482 CFTR_HUMAN (1-1480): 0: 1031: 100.00		DNJB3_HUMAN (1-131): 1.76e-44: 150: 53.44
+	Hs
		529452 CFTR_HUMAN (1-1480): 0: 1031: 100.00		DJB14_HUMAN (2-150): 3.25e-40: 146: 34.67