HitPredict

Interactor 1: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Interactor 2: PDIA3 (P30101)
Protein disulfide-isomerase A3 (EC 5.3.4.1) (58 kDa glucose-regulated protein) (58 kDa microsomal protein) (p58) (Disulfide isomerase ER-60) (Endoplasmic reticulum resident protein 57) (ER protein 57) (ERp57) (Endoplasmic reticulum resident protein 60) (ER protein 60) (ERp60)
Gene: PDIA3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.678

Property	Details
Experiments	26618866, 35156780, 31324722
Identification Methods	affinity chromatography technology, protein complementation assay, cross-linking study, ubiquitin reconstruction, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0009986 - cell surface GO:0034976 - response to endoplasmic reticulum stress GO:0055038 - recycling endosome membrane
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 1480 Hs			1 505
+	Hs
		423122 CFTR_HUMAN (1-1480): 0: 1031: 100.00		PDIA1_HUMAN (3-482): 1.23e-118: 359: 33.68
+	Hs
		529571 CFTR_HUMAN (1-1480): 0: 1031: 100.00		TMX3_HUMAN (375-482): 4.46e-27: 115: 37.27
+	Hs
		529648 CFTR_HUMAN (1-1480): 0: 1031: 100.00		ERP44_HUMAN (368-496): 4.41e-25: 109: 21.64
+	Hs
		528451 CFTR_HUMAN (1-1480): 0: 1031: 100.00		PDIA4_HUMAN (376-505): 1.13e-23: 106: 32.84
+	Hs
		529142 CFTR_HUMAN (1-1480): 0: 1031: 100.00		PDIA6_HUMAN (385-471): 3.13e-10: 64.3: 40.91