HitPredict

Interactor 1: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Interactor 2: HSP74 (P34932)
Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2)
Gene: HSPA4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	0.60	0.709

Property	Details
Experiments	26618866, 17272822, 18556464, 19098309, 18716059
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1480 Hs			1 840
+	Hs
		320805 CFTR_HUMAN (1-1480): 0: 1031: 100.00		HS74L_HUMAN (1-840): 0: 959: 63.21
+	Hs
		529494 CFTR_HUMAN (1-1480): 0: 1031: 100.00		HS105_HUMAN (1-840): 0: 938: 62.95
+	Hs
		714340 MRP2_HUMAN (798-1466): 4.31e-56: 217: 15.74		HSP74_HUMAN (1-840): 0: 993: 100.00
+	Hs
		503344 CFTR_HUMAN (1-1480): 0: 1031: 100.00		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Hs
		483745 CFTR_HUMAN (1-1480): 0: 1031: 100.00		HS71A_HUMAN (571-686): 1.59e-19: 95.5: 23.93
+	Hs
		528659 CFTR_HUMAN (1-1480): 0: 1031: 100.00		HS71L_HUMAN (564-691): 7.22e-19: 93.5: 22.48
+	Hs
		528491 CFTR_HUMAN (1-1480): 0: 1031: 100.00		HSP76_HUMAN (587-690): 1.94e-16: 85.8: 22.86
+	Sc
		694719 YCFI_YEAST (748-1433): 4.8e-56: 216: 14.59		HSP7F_YEAST (5-697): 5.7e-137: 424: 37.61