HitPredict

Interactor 1: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Interactor 2: IF4A3 (P38919)
Eukaryotic initiation factor 4A-III (eIF-4A-III) (eIF4A-III) (EC 3.6.4.13) (ATP-dependent RNA helicase DDX48) (ATP-dependent RNA helicase eIF4A-3) (DEAD box protein 48) (Eukaryotic initiation factor 4A-like NUK-34) (Eukaryotic translation initiation factor 4A isoform 3) (Nuclear matrix protein 265) (NMP 265) (hNMP 265) [Cleaved into: Eukaryotic initiation factor 4A-III, N-terminally processed]
Gene: EIF4A3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	31324722
Identification Methods	cross-linking study
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane and 1 others more... GO:0016887 - ATP hydrolysis activity
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 1480 Hs			1 411
+	Hs
		528864 CFTR_HUMAN (1-1480): 0: 1031: 100.00		IF4A1_HUMAN (7-411): 1.67e-178: 505: 66.75
+	Hs
		529104 CFTR_HUMAN (1-1480): 0: 1031: 100.00		IF4A2_HUMAN (20-411): 4.07e-177: 501: 69.47
+	Hs
		181679 CFTR_HUMAN (1-1480): 0: 1031: 100.00		DDX3Y_HUMAN (17-410): 5.68e-143: 423: 32.45
+	Hs
		528498 CFTR_HUMAN (1-1480): 0: 1031: 100.00		DDX5_HUMAN (25-411): 6.87e-135: 401: 30.63
+	Hs
		133862 CFTR_HUMAN (1-1480): 0: 1031: 100.00		DDX3X_HUMAN (17-410): 2.28e-129: 388: 32.45