HitPredict

Interactor 1: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Interactor 2: NEDD4 (P46934)
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)
Gene: NEDD4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.643

Property	Details
Experiments	25384981, 19617352, 29924966
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0019899 - enzyme binding and 1 others more... GO:0032991 - protein-containing complex
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 1480 Hs			1 1319
+	Hs
		529592 CFTR_HUMAN (1-1480): 0: 1031: 100.00		NED4L_HUMAN (517-1319): 0: 934: 62.26
+	Hs
		529347 CFTR_HUMAN (1-1480): 0: 1031: 100.00		HUWE1_HUMAN (799-1317): 6.4e-169: 562: 35.32
+	Hs
		125126 CFTR_HUMAN (1-1480): 0: 1031: 100.00		WWP2_HUMAN (461-817): 1.56e-41: 167: 17.91
+	Hs
		529568 CFTR_HUMAN (1-1480): 0: 1031: 100.00		ITCH_HUMAN (468-799): 2.73e-28: 125: 19.42