HitPredict

Interactor 1: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Interactor 2: K2C6C (P48668)
Keratin, type II cytoskeletal 6C (Cytokeratin-6C) (CK-6C) (Cytokeratin-6E) (CK-6E) (Keratin K6h) (Keratin-6C) (K6C) (Type-II keratin Kb12)
Gene: KRT6C

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	31324722
Identification Methods	affinity chromatography technology, cross-linking study
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1480 Hs			1 564
+	Hs
		380546 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C1_HUMAN (128-494): 2.73e-165: 486: 73.57
+	Hs
		408988 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C8_HUMAN (135-511): 4.68e-165: 479: 68.70
+	Hs
		444525 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C7_HUMAN (103-534): 3.54e-157: 459: 63.30
+	Mm
		514315 CFTR_MOUSE (1-1468): 0: 957: 78.29		K2C8_MOUSE (80-531): 3.37e-165: 480: 59.03
+	Hs
		529780 CFTR_HUMAN (1-1480): 0: 1031: 100.00		KRT84_HUMAN (1-546): 3.99e-106: 332: 51.37
+	Hs
		318772 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C75_HUMAN (3-564): 1.19e-100: 317: 68.50
+	Hs
		380440 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C6B_HUMAN (1-499): 1.95e-90: 290: 99.00
+	Hs
		528963 CFTR_HUMAN (1-1480): 0: 1031: 100.00		KRT85_HUMAN (1-528): 2.32e-89: 286: 47.73
+	Hs
		529119 CFTR_HUMAN (1-1480): 0: 1031: 100.00		KRT81_HUMAN (47-560): 1.97e-89: 286: 46.72
+	Hs
		213928 CFTR_HUMAN (1-1480): 0: 1031: 100.00		KRT86_HUMAN (47-535): 1.1e-87: 281: 48.06
+	Hs
		359458 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C6A_HUMAN (1-499): 5.37e-86: 279: 98.40
+	Hs
		528450 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C5_HUMAN (3-486): 5.94e-85: 277: 77.35
+	Hs
		529130 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C72_HUMAN (8-554): 1.32e-76: 253: 55.76
+	Hs
		529332 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C74_HUMAN (3-563): 2.63e-76: 252: 51.87
+	Hs
		529349 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C1B_HUMAN (56-494): 6.31e-66: 226: 61.36
+	Hs
		529503 CFTR_HUMAN (1-1480): 0: 1031: 100.00		KRT35_HUMAN (47-476): 3.24e-65: 221: 25.12