HitPredict

Interactor 1: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Interactor 2: RAN (P62826)
GTP-binding nuclear protein Ran (EC 3.6.5.-) (Androgen receptor-associated protein 24) (GTPase Ran) (Ras-like protein TC4) (Ras-related nuclear protein)
Gene: RAN

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.650

Property	Details
Experiments	31324722, 17110338, 29924966
Identification Methods	affinity chromatography technology, pull down, cross-linking study
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane GO:0032991 - protein-containing complex and 1 others more... GO:0055037 - recycling endosome
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1480 Hs			1 216
+	Hs
		528909 CFTR_HUMAN (1-1480): 0: 1031: 100.00		RB11A_HUMAN (4-207): 7.68e-78: 234: 25.94
+	Hs
		528797 CFTR_HUMAN (1-1480): 0: 1031: 100.00		RAB7A_HUMAN (8-166): 7.44e-29: 108: 33.13
+	Hs
		528528 CFTR_HUMAN (1-1480): 0: 1031: 100.00		RAB4A_HUMAN (11-169): 1.53e-27: 105: 34.57
+	Hs
		706711 MRP1_HUMAN (810-1471): 5.31e-60: 229: 15.70		RAB35_HUMAN (6-188): 1.31e-87: 258: 29.19
+	Hs
		179413 MRP5_HUMAN (774-1479): 5.77e-53: 207: 13.26		RAB35_HUMAN (6-188): 1.31e-87: 258: 29.19
+	Hs
		706699 MRP1_HUMAN (810-1471): 5.31e-60: 229: 15.70		RB11A_HUMAN (4-207): 7.68e-78: 234: 25.94
+	Hs
		179346 MRP4_HUMAN (5-647): 2.25e-59: 227: 15.67		RAB7A_HUMAN (8-166): 7.44e-29: 108: 33.13