HitPredict

Interactor 1: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Interactor 2: UBE3A (Q05086)
Ubiquitin-protein ligase E3A (EC 2.3.2.26) (E6AP ubiquitin-protein ligase) (HECT-type ubiquitin transferase E3A) (Human papillomavirus E6-associated protein) (Oncogenic protein-associated protein E6-AP) (Renal carcinoma antigen NY-REN-54)
Gene: UBE3A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	17110338
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 1480 Hs			1 875
+	Hs
		528744 CFTR_HUMAN (1-1480): 0: 1031: 100.00		NEDD4_HUMAN (46-873): 0: 622: 21.49
+	Hs
		125126 CFTR_HUMAN (1-1480): 0: 1031: 100.00		WWP2_HUMAN (291-873): 0: 589: 24.72
+	Hs
		529568 CFTR_HUMAN (1-1480): 0: 1031: 100.00		ITCH_HUMAN (325-873): 0: 579: 24.78
+	Hs
		529592 CFTR_HUMAN (1-1480): 0: 1031: 100.00		NED4L_HUMAN (247-873): 0: 575: 22.52
+	Hs
		529347 CFTR_HUMAN (1-1480): 0: 1031: 100.00		HUWE1_HUMAN (523-874): 5.96e-53: 203: 33.97
+	Hs
		529156 CFTR_HUMAN (1-1480): 0: 1031: 100.00		UBE3C_HUMAN (453-872): 2.23e-52: 200: 32.27