HitPredict

Interactor 1: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Interactor 2: DCTN1 (Q14203)
Dynactin subunit 1 (150 kDa dynein-associated polypeptide) (DAP-150) (DP-150) (p135) (p150-glued)
Gene: DCTN1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	26618866, 31324722
Identification Methods	affinity chromatography technology, cross-linking study, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 1480 Hs			1 1278
+	Hs
		522533 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH1_HUMAN (374-1278): 2.47e-39: 162: 10.82
+	Hs
		522586 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH7_HUMAN (64-763): 2.65e-27: 122: 9.80
+	Hs
		528357 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH6_HUMAN (47-712): 5.82e-26: 118: 9.71
+	Hs
		528676 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH10_HUMAN (664-1275): 2.12e-23: 110: 10.13
+	Hs
		528626 CFTR_HUMAN (1-1480): 0: 1031: 100.00		CLIP1_HUMAN (111-828): 1.9e-21: 103: 11.32
+	Hs
		529896 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH13_HUMAN (637-1278): 2.11e-21: 103: 10.87
+	Hs
		529972 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH4_HUMAN (726-1276): 1.05e-18: 94.9: 10.20
+	Hs
		528675 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH9_HUMAN (805-1271): 6.9e-15: 82.5: 11.54
+	Hs
		529895 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH2_HUMAN (830-1278): 9.73e-15: 81.8: 8.67
+	Hs
		528484 CFTR_HUMAN (1-1480): 0: 1031: 100.00		DESP_HUMAN (227-1049): 1.36e-14: 81.5: 14.64
+	Hs
		502902 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH3_HUMAN (830-1278): 8.46e-13: 75.6: 10.11
+	Hs
		528682 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH11_HUMAN (49-439): 7.24e-12: 72.5: 9.16
+	Hs
		528400 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH8_HUMAN (62-436): 3.47e-11: 70.2: 11.05