HitPredict

Interactor 1: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Interactor 2: NHRF3 (Q5T2W1)
Na(+)/H(+) exchange regulatory cofactor NHE-RF3 (NHERF-3) (CFTR-associated protein of 70 kDa) (Na(+)/H(+) exchanger regulatory factor 3) (Na/Pi cotransporter C-terminal-associated protein 1) (NaPi-Cap1) (PDZ domain-containing protein 1) (Sodium-hydrogen exchanger regulatory factor 3)
Gene: PDZK1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.675

Property	Details
Experiments	12471024, 11051556, 18045536
Identification Methods	pull down, affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0016324 - apical plasma membrane GO:0030165 - PDZ domain binding
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 1480 Hs			1 519
+	Hs
		529355 CFTR_HUMAN (1-1480): 0: 1031: 100.00		NHRF4_HUMAN (120-505): 7.2e-35: 139: 23.33
+	Hs
		153866 CFTR_HUMAN (1-1480): 0: 1031: 100.00		NHRF1_HUMAN (5-134): 6.99e-24: 104: 31.54
+	Hs
		529099 CFTR_HUMAN (1-1480): 0: 1031: 100.00		SCRIB_HUMAN (125-505): 6.83e-20: 96: 10.97
+	Hs
		529166 CFTR_HUMAN (1-1480): 0: 1031: 100.00		NHRF2_HUMAN (5-146): 7.72e-20: 92.8: 28.17
+	Hs
		529050 CFTR_HUMAN (1-1480): 0: 1031: 100.00		DLG1_HUMAN (289-461): 1.6e-16: 85.1: 18.52
+	Mm
		641306 CFTR_MOUSE (1-1468): 0: 957: 78.29		NHRF1_MOUSE (2-264): 1.2e-38: 146: 30.04
+	Hs
		179363 MRP4_HUMAN (5-647): 2.25e-59: 227: 15.67		NHRF3_HUMAN (1-519): 1.87e-114: 350: 100.00
+	Hs
		1132912 MRP2_HUMAN (798-1466): 4.31e-56: 217: 15.74		NHRF3_HUMAN (1-519): 1.87e-114: 350: 100.00
+	Rn
		1144126 MRP2_RAT (773-1466): 1.07e-55: 215: 15.08		NHRF1_RAT (2-264): 2.21e-38: 145: 29.09
+	Hs
		1200079 MRP2_HUMAN (798-1466): 4.31e-56: 217: 15.74		NHRF4_HUMAN (120-505): 7.2e-35: 139: 23.33
+	Hs
		153846 MRP4_HUMAN (5-647): 2.25e-59: 227: 15.67		NHRF1_HUMAN (5-134): 6.99e-24: 104: 31.54
+	Hs
		179356 MRP4_HUMAN (5-647): 2.25e-59: 227: 15.67		SCRIB_HUMAN (125-505): 6.83e-20: 96: 10.97
+	Hs
		153939 MRP2_HUMAN (798-1466): 4.31e-56: 217: 15.74		NHRF1_HUMAN (5-134): 6.99e-24: 104: 31.54
+	Hs
		179358 MRP4_HUMAN (5-647): 2.25e-59: 227: 15.67		NHRF2_HUMAN (5-146): 7.72e-20: 92.8: 28.17
+	Hs
		67899 MRP4_HUMAN (5-647): 2.25e-59: 227: 15.67		PDZ1P_HUMAN (6-134): 6.25e-18: 87.9: 28.68