HitPredict

Interactor 1: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Interactor 2: K2C74 (Q7RTS7)
Keratin, type II cytoskeletal 74 (Cytokeratin-74) (CK-74) (Keratin-5c) (K5C) (Keratin-74) (K74) (Type II inner root sheath-specific keratin-K6irs4) (Type-II keratin Kb37)
Gene: KRT74

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	31324722
Identification Methods	affinity chromatography technology, cross-linking study
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1480 Hs			1 529
+	Hs
		380546 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C1_HUMAN (105-471): 4.75e-164: 481: 66.21
+	Hs
		528683 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K22E_HUMAN (112-456): 3.26e-150: 446: 67.54
+	Hs
		529396 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C78_HUMAN (78-470): 1.81e-132: 396: 58.78
+	Hs
		408988 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C8_HUMAN (112-480): 3.62e-130: 389: 58.81
+	Hs
		444525 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C7_HUMAN (45-467): 1.88e-130: 389: 56.50
+	Hs
		529349 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C1B_HUMAN (45-471): 3.4e-110: 341: 57.27
+	Hs
		529780 CFTR_HUMAN (1-1480): 0: 1031: 100.00		KRT84_HUMAN (3-453): 1.3e-104: 327: 49.58
+	Hs
		318772 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C75_HUMAN (1-465): 1.1e-95: 302: 58.49
+	Hs
		529119 CFTR_HUMAN (1-1480): 0: 1031: 100.00		KRT81_HUMAN (6-453): 7.89e-95: 299: 45.58
+	Hs
		213928 CFTR_HUMAN (1-1480): 0: 1031: 100.00		KRT86_HUMAN (6-453): 2.1e-93: 295: 45.58
+	Hs
		528963 CFTR_HUMAN (1-1480): 0: 1031: 100.00		KRT85_HUMAN (3-453): 5.23e-93: 294: 48.03
+	Hs
		529130 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C72_HUMAN (1-529): 8.23e-87: 278: 69.00
+	Hs
		528450 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C5_HUMAN (1-456): 7.45e-82: 267: 58.68
+	Hs
		380440 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C6B_HUMAN (8-472): 3.98e-81: 265: 57.00
+	Hs
		528760 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C6C_HUMAN (8-472): 1.23e-80: 264: 57.00
+	Hs
		359458 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C6A_HUMAN (8-472): 9.42e-78: 256: 57.20
+	Hs
		529503 CFTR_HUMAN (1-1480): 0: 1031: 100.00		KRT35_HUMAN (37-453): 2.21e-69: 231: 24.22