HitPredict

Interactor 1: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Interactor 2: MIRO1 (Q8IXI2)
Mitochondrial Rho GTPase 1 (MIRO-1) (hMiro-1) (EC 3.6.5.-) (Rac-GTP-binding protein-like protein) (Ras homolog gene family member T1)
Gene: RHOT1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	17110338
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1480 Hs			1 618
+	Hs
		529383 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MIRO2_HUMAN (1-618): 0: 764: 59.81
+	Hs
		528936 CFTR_HUMAN (1-1480): 0: 1031: 100.00		RAC1_HUMAN (3-181): 7.62e-73: 234: 23.83
+	Hs
		528909 CFTR_HUMAN (1-1480): 0: 1031: 100.00		RB11A_HUMAN (5-201): 1.75e-71: 231: 19.60
+	Hs
		528476 CFTR_HUMAN (1-1480): 0: 1031: 100.00		RAC2_HUMAN (3-185): 6.9e-70: 226: 23.86
+	Hs
		528880 CFTR_HUMAN (1-1480): 0: 1031: 100.00		RHOA_HUMAN (6-186): 1.33e-65: 214: 23.59
+	Hs
		706702 MRP1_HUMAN (810-1471): 5.31e-60: 229: 15.70		RAC1_HUMAN (3-181): 7.62e-73: 234: 23.83
+	Hs
		706711 MRP1_HUMAN (810-1471): 5.31e-60: 229: 15.70		RAB35_HUMAN (5-168): 1.96e-72: 233: 25.90
+	Hs
		706699 MRP1_HUMAN (810-1471): 5.31e-60: 229: 15.70		RB11A_HUMAN (5-201): 1.75e-71: 231: 19.60
+	Hs
		545225 MRP1_HUMAN (810-1471): 5.31e-60: 229: 15.70		RAC2_HUMAN (3-185): 6.9e-70: 226: 23.86
+	Hs
		706692 MRP1_HUMAN (810-1471): 5.31e-60: 229: 15.70		RAC3_HUMAN (3-168): 4.28e-70: 226: 23.89
+	Hs
		706705 MRP1_HUMAN (810-1471): 5.31e-60: 229: 15.70		RHOG_HUMAN (3-170): 8.87e-68: 220: 25.28
+	Hs
		706695 MRP1_HUMAN (810-1471): 5.31e-60: 229: 15.70		RHOA_HUMAN (6-186): 1.33e-65: 214: 23.59
+	Hs
		179393 MRP5_HUMAN (774-1479): 5.77e-53: 207: 13.26		RAC2_HUMAN (3-185): 6.9e-70: 226: 23.86
+	Hs
		179400 MRP5_HUMAN (774-1479): 5.77e-53: 207: 13.26		RAC3_HUMAN (3-168): 4.28e-70: 226: 23.89
+	Hs
		120319 MRP1_HUMAN (810-1471): 5.31e-60: 229: 15.70		RHOD_HUMAN (3-171): 2.64e-11: 65.5: 27.87
+	Hs
		706733 MRP1_HUMAN (810-1471): 5.31e-60: 229: 15.70		RHOF_HUMAN (2-167): 3.85e-11: 64.7: 28.33
+	Hs
		706700 MRP1_HUMAN (810-1471): 5.31e-60: 229: 15.70		RHOB_HUMAN (6-168): 6.46e-10: 60.8: 25.99
+	Hs
		564426 MRP1_HUMAN (810-1471): 5.31e-60: 229: 15.70		RHOQ_HUMAN (5-169): 8.64e-09: 57.8: 27.37
+	Hs
		120217 MRP5_HUMAN (774-1479): 5.77e-53: 207: 13.26		RHOD_HUMAN (3-171): 2.64e-11: 65.5: 27.87
+	Hs
		179395 MRP5_HUMAN (774-1479): 5.77e-53: 207: 13.26		RHOQ_HUMAN (5-169): 8.64e-09: 57.8: 27.37