HitPredict

Interactor 1: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Interactor 2: HS105 (Q92598)
Heat shock protein 105 kDa (Antigen NY-CO-25) (Heat shock 110 kDa protein) (Heat shock protein family H member 1)
Gene: HSPH1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	26618866, 31324722, 17110338
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0032991 - protein-containing complex
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 1480 Hs			1 858
+	Hs
		320805 CFTR_HUMAN (1-1480): 0: 1031: 100.00		HS74L_HUMAN (1-858): 0: 953: 57.46
+	Hs
		528660 CFTR_HUMAN (1-1480): 0: 1031: 100.00		HSP74_HUMAN (1-858): 0: 917: 60.98
+	Hs
		529960 CFTR_HUMAN (1-1480): 0: 1031: 100.00		HYOU1_HUMAN (1-839): 2.83e-81: 284: 27.41
+	Hs
		503344 CFTR_HUMAN (1-1480): 0: 1031: 100.00		HSP7C_HUMAN (489-709): 2.48e-32: 135: 11.26
+	Hs
		483745 CFTR_HUMAN (1-1480): 0: 1031: 100.00		HS71A_HUMAN (586-707): 8.57e-31: 131: 21.14
+	Hs
		528659 CFTR_HUMAN (1-1480): 0: 1031: 100.00		HS71L_HUMAN (586-716): 7.63e-31: 131: 19.70
+	Hs
		528491 CFTR_HUMAN (1-1480): 0: 1031: 100.00		HSP76_HUMAN (604-707): 8.59e-27: 118: 22.86
+	Hs
		714340 MRP2_HUMAN (798-1466): 4.31e-56: 217: 15.74		HSP74_HUMAN (1-858): 0: 917: 60.98
+	Sc
		694719 YCFI_YEAST (748-1433): 4.8e-56: 216: 14.59		HSP7F_YEAST (5-730): 7.71e-136: 422: 36.92