HitPredict

Interactor 1: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Interactor 2: EVPL (Q92817)
Envoplakin (210 kDa cornified envelope precursor protein) (210 kDa paraneoplastic pemphigus antigen) (p210)
Gene: EVPL

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	31324722
Identification Methods	cross-linking study
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1480 Hs			1 2033
+	Hs
		528676 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH10_HUMAN (1121-2019): 1.8e-30: 134: 8.80
+	Hs
		528400 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH8_HUMAN (1-788): 3.5e-29: 130: 9.54
+	Hs
		522586 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH7_HUMAN (1178-1941): 3.48e-23: 110: 9.23
+	Hs
		529495 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MY18A_HUMAN (593-1184): 9.18e-23: 109: 15.26
+	Hs
		522533 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH1_HUMAN (1130-1919): 1.71e-22: 108: 9.98
+	Hs
		529972 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH4_HUMAN (1134-1919): 1.4e-21: 105: 10.53
+	Hs
		529896 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH13_HUMAN (1262-1999): 8.26e-20: 99.6: 9.97
+	Hs
		234182 CFTR_HUMAN (1-1480): 0: 1031: 100.00		PEPL_HUMAN (1-715): 5.64e-18: 93.4: 11.39
+	Hs
		529895 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH2_HUMAN (1466-1942): 4.11e-16: 87.2: 11.23
+	Hs
		528357 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH6_HUMAN (1466-1942): 2.02e-15: 84.9: 8.81
+	Hs
		528682 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH11_HUMAN (7-518): 5.15e-15: 83.8: 9.09
+	Hs
		529144 CFTR_HUMAN (1-1480): 0: 1031: 100.00		PLEC_HUMAN (1836-2029): 1.64e-13: 78.8: 34.02
+	Hs
		528675 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH9_HUMAN (849-1682): 3.31e-12: 74.3: 20.96
+	Hs
		528852 CFTR_HUMAN (1-1480): 0: 1031: 100.00		EPIPL_HUMAN (1498-2013): 1.02e-11: 73.1: 17.14
+	Hs
		529003 CFTR_HUMAN (1-1480): 0: 1031: 100.00		DYST_HUMAN (654-1975): 1.61e-10: 69.1: 10.69
+	Hs
		529917 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MACF1_HUMAN (84-934): 1.52e-10: 69.1: 12.49
+	Hs
		502902 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH3_HUMAN (1-484): 2.77e-10: 68: 11.36
+	Hs
		528984 CFTR_HUMAN (1-1480): 0: 1031: 100.00		SPTB2_HUMAN (29-551): 3.68e-09: 64.5: 10.00
+	Hs
		528484 CFTR_HUMAN (1-1480): 0: 1031: 100.00		DESP_HUMAN (16-479): 4.67e-09: 64.1: 8.49
+	Zm
		32553 K7VCA6_MAIZE (110-652): 2.14e-62: 237: 16.58		A0A1D6KUY8_MAIZE (10-1576): 1.25e-29: 131: 10.49