HitPredict

Interactor 1: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Interactor 2: SNX27 (Q96L92)
Sorting nexin-27
Gene: SNX27

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	26618866
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005769 - early endosome GO:0005829 - cytosol GO:0031901 - early endosome membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1480 Hs			1 541
+	Hs
		528787 CFTR_HUMAN (1-1480): 0: 1031: 100.00		PDLI4_HUMAN (41-261): 3.86e-30: 122: 16.14
+	Hs
		529790 CFTR_HUMAN (1-1480): 0: 1031: 100.00		LIN7C_HUMAN (35-136): 1.5e-27: 111: 34.95
+	Hs
		529166 CFTR_HUMAN (1-1480): 0: 1031: 100.00		NHRF2_HUMAN (9-207): 1.8e-24: 106: 21.78
+	Hs
		153866 CFTR_HUMAN (1-1480): 0: 1031: 100.00		NHRF1_HUMAN (12-209): 7.91e-23: 101: 22.89
+	Hs
		529235 CFTR_HUMAN (1-1480): 0: 1031: 100.00		NHRF3_HUMAN (38-313): 4.98e-16: 82.7: 13.70
+	Hs
		529026 CFTR_HUMAN (1-1480): 0: 1031: 100.00		ZO1_HUMAN (4-254): 7.48e-12: 70.3: 13.97
+	Hs
		529355 CFTR_HUMAN (1-1480): 0: 1031: 100.00		NHRF4_HUMAN (8-146): 1.15e-11: 69.2: 21.99
+	Rn
		710153 CFTR_RAT (1-1468): 0: 938: 77.81		SHAN2_RAT (43-147): 1.03e-28: 123: 38.10
+	Mm
		641306 CFTR_MOUSE (1-1468): 0: 957: 78.29		NHRF1_MOUSE (5-248): 2.06e-23: 103: 18.95
+	Hs
		179374 MRP4_HUMAN (5-647): 2.25e-59: 227: 15.67		SNX27_HUMAN (1-541): 0: 625: 100.00
+	Hs
		179354 MRP4_HUMAN (5-647): 2.25e-59: 227: 15.67		SNTA1_HUMAN (1-188): 2.48e-29: 123: 20.10
+	Hs
		179358 MRP4_HUMAN (5-647): 2.25e-59: 227: 15.67		NHRF2_HUMAN (9-207): 1.8e-24: 106: 21.78
+	Hs
		153846 MRP4_HUMAN (5-647): 2.25e-59: 227: 15.67		NHRF1_HUMAN (12-209): 7.91e-23: 101: 22.89
+	Rn
		1144126 MRP2_RAT (773-1466): 1.07e-55: 215: 15.08		NHRF1_RAT (6-208): 4.22e-24: 105: 21.68
+	Hs
		1272174 MRP2_HUMAN (798-1466): 4.31e-56: 217: 15.74		SHAN3_HUMAN (44-148): 1.57e-21: 101: 37.14
+	Hs
		153939 MRP2_HUMAN (798-1466): 4.31e-56: 217: 15.74		NHRF1_HUMAN (12-209): 7.91e-23: 101: 22.89
+	Hs
		179363 MRP4_HUMAN (5-647): 2.25e-59: 227: 15.67		NHRF3_HUMAN (38-313): 4.98e-16: 82.7: 13.70
+	Hs
		67899 MRP4_HUMAN (5-647): 2.25e-59: 227: 15.67		PDZ1P_HUMAN (38-282): 1.35e-15: 80.7: 14.23
+	Hs
		1132912 MRP2_HUMAN (798-1466): 4.31e-56: 217: 15.74		NHRF3_HUMAN (38-313): 4.98e-16: 82.7: 13.70
+	Hs
		1200079 MRP2_HUMAN (798-1466): 4.31e-56: 217: 15.74		NHRF4_HUMAN (8-146): 1.15e-11: 69.2: 21.99