HitPredict

Interactor 1: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Interactor 2: MYH2 (Q9UKX2)
Myosin-2 (Myosin heavy chain 2) (Myosin heavy chain 2a) (MyHC-2a) (Myosin heavy chain IIa) (MyHC-IIa) (Myosin heavy chain, skeletal muscle, adult 2)
Gene: MYH2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	26618866
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0032991 - protein-containing complex
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 1480 Hs			1 1941
+	Hs
		522586 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH7_HUMAN (3-1933): 0: 1123: 81.10
+	Hs
		522533 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH1_HUMAN (1-1941): 0: 1115: 94.54
+	Hs
		529972 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH4_HUMAN (1-1941): 0: 1113: 91.40
+	Hs
		528357 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH6_HUMAN (3-1933): 0: 1090: 80.22
+	Hs
		528675 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH9_HUMAN (28-1932): 0: 929: 39.90
+	Hs
		528400 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH8_HUMAN (931-1941): 1.18e-60: 233: 17.85
+	Hs
		528676 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH10_HUMAN (987-1941): 1.59e-60: 233: 18.69
+	Hs
		529896 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH13_HUMAN (987-1941): 1.59e-57: 223: 18.98
+	Hs
		528682 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH11_HUMAN (718-1597): 9.25e-43: 174: 14.62
+	Hs
		529340 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH14_HUMAN (771-1412): 9.53e-21: 102: 14.56
+	Hs
		64579 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH7B_HUMAN (741-1208): 2.23e-17: 91.3: 14.83
+	Hs
		502902 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH3_HUMAN (732-1213): 4.32e-15: 84: 13.31