HitPredict

Interactor 1: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Interactor 2: MACF1 (Q9UPN3)
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha)
Gene: MACF1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	31324722
Identification Methods	affinity chromatography technology, cross-linking study
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0016020 - membrane
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 1480 Hs			1 7388
+	Hs
		528852 CFTR_HUMAN (1-1480): 0: 1031: 100.00		EPIPL_HUMAN (1538-2789): 1.49e-35: 154: 13.15
+	Hs
		528484 CFTR_HUMAN (1-1480): 0: 1031: 100.00		DESP_HUMAN (2737-3775): 9.21e-27: 124: 8.65
+	Hs
		529144 CFTR_HUMAN (1-1480): 0: 1031: 100.00		PLEC_HUMAN (2677-3656): 8.53e-27: 124: 8.13
+	Hs
		529029 CFTR_HUMAN (1-1480): 0: 1031: 100.00		ACTN3_HUMAN (5633-6111): 4.77e-17: 92.1: 12.20
+	Hs
		513826 CFTR_HUMAN (1-1480): 0: 1031: 100.00		DMD_HUMAN (239-1700): 1.65e-14: 84.4: 8.22
+	Hs
		529003 CFTR_HUMAN (1-1480): 0: 1031: 100.00		DYST_HUMAN (478-1511): 2.31e-12: 77.1: 9.72
+	Hs
		528984 CFTR_HUMAN (1-1480): 0: 1031: 100.00		SPTB2_HUMAN (6378-7134): 6.05e-11: 72.5: 13.80
+	Hs
		521456 CFTR_HUMAN (1-1480): 0: 1031: 100.00		ACTN1_HUMAN (921-1398): 1.47e-10: 70.5: 9.07
+	Hs
		529088 CFTR_HUMAN (1-1480): 0: 1031: 100.00		SPTN1_HUMAN (433-1344): 7.43e-10: 68.8: 13.39