HitPredict

Interactor 1: ITA4 (P13612)
Integrin alpha-4 (CD49 antigen-like family member D) (Integrin alpha-IV) (VLA-4 subunit alpha) (CD antigen CD49d)
Gene: ITGA4

Interactor 2: ITB7 (P26010)
Integrin beta-7 (Gut homing receptor beta subunit)
Gene: ITGB7

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.68 1.00 0.829

The method score is based on:

Property Details
Experiments 22232704, 1542691, 14681217
Identification Methods x-ray crystallography, anti bait coimmunoprecipitation, lex-a dimerization assay
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains FG-GAP~Integrin_beta, EGF_2~Integrin_alpha2, Integrin_alpha2~Integrin_beta, Integrin_alpha2~PSI_integrin
Common GO terms GO:0002387 - immune response in gut-associated lymphoid tissue
GO:0003366 - cell-matrix adhesion involved in ameboidal cell migration
GO:0005178 - integrin binding
GO:0005886 - plasma membrane
GO:0005925 - focal adhesion
and 15 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Hs

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Last updated: 15 Jul 2024