HitPredict

Interactor 1: K1C10 (P13645)
Keratin, type I cytoskeletal 10 (Cytokeratin-10) (CK-10) (Keratin-10) (K10)
Gene: KRT10

Interactor 2: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	19380743
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 584 Hs			1 583
+	Hs
		666076 K1C17_HUMAN (140-456): 6.22e-150: 440: 70.03		SHC1_HUMAN (1-583): 0: 531: 100.00
+	Hs
		359306 K1C14_HUMAN (144-457): 1.33e-144: 427: 69.43		SHC1_HUMAN (1-583): 0: 531: 100.00
+	Hs
		531449 K1C13_HUMAN (135-471): 4.47e-144: 425: 63.50		SHC1_HUMAN (1-583): 0: 531: 100.00
+	Hs
		445008 K1C16_HUMAN (142-456): 9.28e-143: 423: 67.62		SHC1_HUMAN (1-583): 0: 531: 100.00
+	Hs
		1071309 K1H1_HUMAN (139-464): 3.37e-140: 414: 53.68		SHC3_HUMAN (6-582): 3.32e-127: 387: 45.47
+	Hs
		1071190 K1H1_HUMAN (139-464): 3.37e-140: 414: 53.68		Q49AR9_HUMAN (40-425): 1.96e-47: 176: 18.14
+	Hs
		1071311 K1H1_HUMAN (139-464): 3.37e-140: 414: 53.68		ANS1A_HUMAN (40-393): 2.28e-42: 165: 18.41
+	Hs
		442835 K1H1_HUMAN (139-464): 3.37e-140: 414: 53.68		HCK_HUMAN (348-575): 2.72e-43: 164: 17.16
+	Hs
		129281 K1C17_HUMAN (140-456): 6.22e-150: 440: 70.03		P85B_HUMAN (358-581): 2.69e-29: 125: 17.47
+	Hs
		129187 K1C10_HUMAN (141-454): 1.05e-147: 439: 100.00		P85B_HUMAN (358-581): 2.69e-29: 125: 17.47
+	Hs
		129154 K1C14_HUMAN (144-457): 1.33e-144: 427: 69.43		P85B_HUMAN (358-581): 2.69e-29: 125: 17.47
+	Hs
		129174 K1C16_HUMAN (142-456): 9.28e-143: 423: 67.62		P85B_HUMAN (358-581): 2.69e-29: 125: 17.47
+	Hs
		129196 K1C15_HUMAN (130-462): 8.09e-141: 417: 65.47		P85B_HUMAN (358-581): 2.69e-29: 125: 17.47
+	Hs
		924493 K1C17_HUMAN (140-456): 6.22e-150: 440: 70.03		GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48
+	Hs
		531343 K1C10_HUMAN (141-454): 1.05e-147: 439: 100.00		GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48
+	Hs
		359329 K1C14_HUMAN (144-457): 1.33e-144: 427: 69.43		GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48
+	Hs
		445027 K1C16_HUMAN (142-456): 9.28e-143: 423: 67.62		GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48
+	Hs
		580010 K1C15_HUMAN (130-462): 8.09e-141: 417: 65.47		GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48
+	Hs
		129218 K1C9_HUMAN (141-455): 3.9e-117: 362: 57.14		P85B_HUMAN (358-581): 2.69e-29: 125: 17.47
+	Hs
		444346 K1C19_HUMAN (140-456): 2.13e-136: 404: 65.30		GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48