HitPredict

Interactor 1: K2C5 (P13647)
Keratin, type II cytoskeletal 5 (58 kDa cytokeratin) (Cytokeratin-5) (CK-5) (Keratin-5) (K5) (Type-II keratin Kb5)
Gene: KRT5

Interactor 2: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	19380743
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane GO:0070062 - extracellular exosome and 1 others more... GO:0097110 - scaffold protein binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 590 Hs			1 304
+	Hs
		517743 K2C3_HUMAN (140-484): 3.95e-178: 519: 78.10		CRK_HUMAN (1-304): 7.82e-68: 215: 100.00
+	Hs
		729048 K22E_HUMAN (140-484): 3.01e-174: 509: 71.88		CRK_HUMAN (1-304): 7.82e-68: 215: 100.00
+	Hs
		409026 K2C8_HUMAN (140-516): 1.46e-162: 474: 69.23		CRK_HUMAN (1-304): 7.82e-68: 215: 100.00
+	Hs
		409124 K2C8_HUMAN (140-516): 1.46e-162: 474: 69.23		DNMBP_HUMAN (119-293): 5.7e-46: 168: 29.35
+	Hs
		729063 K22E_HUMAN (140-484): 3.01e-174: 509: 71.88		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		409046 K2C8_HUMAN (140-516): 1.46e-162: 474: 69.23		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		444533 K2C7_HUMAN (74-494): 9.68e-163: 474: 65.09		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		802647 K2C73_HUMAN (1-589): 1.2e-95: 304: 51.78		CRK_HUMAN (1-304): 7.82e-68: 215: 100.00
+	Hs
		380448 K2C6B_HUMAN (2-503): 6.66e-84: 274: 79.08		CRK_HUMAN (1-304): 7.82e-68: 215: 100.00
+	Hs
		359471 K2C6A_HUMAN (2-563): 4.45e-79: 261: 74.20		CRK_HUMAN (1-304): 7.82e-68: 215: 100.00
+	Hs
		802619 K2C79_HUMAN (55-497): 2.34e-79: 261: 66.74		CRK_HUMAN (1-304): 7.82e-68: 215: 100.00
+	Hs
		802568 K22O_HUMAN (1-496): 3.11e-67: 232: 62.74		CRK_HUMAN (1-304): 7.82e-68: 215: 100.00
+	Hs
		924679 K2C73_HUMAN (1-589): 1.2e-95: 304: 51.78		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		531551 K2C5_HUMAN (1-590): 4.15e-92: 296: 100.00		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		924469 KRT83_HUMAN (57-550): 3.21e-86: 278: 48.08		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		924576 KRT81_HUMAN (56-576): 6.11e-86: 278: 45.68		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		924470 KRT85_HUMAN (1-528): 7.95e-85: 275: 47.55		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		213936 KRT86_HUMAN (49-483): 4.59e-84: 272: 50.81		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		359480 K2C6A_HUMAN (2-563): 4.45e-79: 261: 74.20		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		924895 KRT82_HUMAN (52-561): 3.72e-79: 260: 47.95		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67