HitPredict

Interactor 1: PDIA4 (P13667)
Protein disulfide-isomerase A4 (EC 5.3.4.1) (Endoplasmic reticulum resident protein 70) (ER protein 70) (ERp70) (Endoplasmic reticulum resident protein 72) (ER protein 72) (ERp-72) (ERp72)
Gene: PDIA4

Interactor 2: NTRK3 (Q16288)
NT-3 growth factor receptor (EC 2.7.10.1) (GP145-TrkC) (Trk-C) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase)
Gene: NTRK3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.50	0.457

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 645 Hs			1 839
+	Hs
		384191 PDIA4_HUMAN (1-645): 0: 571: 100.00		NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75
+	Hs
		507820 PDIA4_HUMAN (1-645): 0: 571: 100.00		FGFR1_HUMAN (162-838): 5.94e-163: 496: 23.43
+	Hs
		531720 PDIA4_HUMAN (1-645): 0: 571: 100.00		FGFR4_HUMAN (166-837): 6.43e-152: 466: 24.57
+	Hs
		434126 PDIA4_HUMAN (1-645): 0: 571: 100.00		RET_HUMAN (282-837): 1.5e-108: 360: 25.76
+	Hs
		1081525 DJC10_HUMAN (41-295): 2.22e-45: 174: 22.47		NTRK3_HUMAN (1-839): 0: 671: 100.00
+	Hs
		411285 PDIA4_HUMAN (1-645): 0: 571: 100.00		INSR_HUMAN (513-824): 1.34e-64: 238: 39.43
+	Hs
		435520 PDIA4_HUMAN (1-645): 0: 571: 100.00		IGF1R_HUMAN (513-820): 3.56e-64: 236: 39.16
+	Hs
		532019 PDIA4_HUMAN (1-645): 0: 571: 100.00		ALK_HUMAN (513-816): 2.78e-59: 222: 39.03
+	Rn
		102493 G3V6T7_RAT (25-645): 0: 550: 87.28		INSR_RAT (513-824): 3.31e-62: 230: 38.80
+	Hs
		385136 DJC10_HUMAN (41-295): 2.22e-45: 174: 22.47		NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75
+	Hs
		384104 PDIA1_HUMAN (4-165): 4.25e-32: 132: 27.11		NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75
+	Hs
		423118 PDIA1_HUMAN (4-165): 4.25e-32: 132: 27.11		FGFR1_HUMAN (162-838): 5.94e-163: 496: 23.43
+	Hs
		968425 DJC10_HUMAN (41-295): 2.22e-45: 174: 22.47		ROR2_HUMAN (522-828): 2.97e-67: 243: 41.56
+	Rn
		544870 PDIA6_RAT (392-645): 4.37e-51: 185: 19.85		INSR_RAT (513-824): 3.31e-62: 230: 38.80
+	Hs
		411430 DJC10_HUMAN (41-295): 2.22e-45: 174: 22.47		INSR_HUMAN (513-824): 1.34e-64: 238: 39.43
+	Hs
		435692 DJC10_HUMAN (41-295): 2.22e-45: 174: 22.47		IGF1R_HUMAN (513-820): 3.56e-64: 236: 39.16
+	Hs
		537757 DJC10_HUMAN (41-295): 2.22e-45: 174: 22.47		INSRR_HUMAN (513-820): 1.33e-62: 231: 40.84
+	Hs
		411271 PDIA1_HUMAN (4-165): 4.25e-32: 132: 27.11		INSR_HUMAN (513-824): 1.34e-64: 238: 39.43
+	Hs
		423108 PDIA1_HUMAN (4-165): 4.25e-32: 132: 27.11		IGF1R_HUMAN (513-820): 3.56e-64: 236: 39.16
+	Rn
		388065 PDIA1_RAT (4-197): 4.14e-32: 132: 25.25		INSR_RAT (513-824): 3.31e-62: 230: 38.80