HitPredict

Interactor 1: PDIA4 (P13667)
Protein disulfide-isomerase A4 (EC 5.3.4.1) (Endoplasmic reticulum resident protein 70) (ER protein 70) (ERp70) (Endoplasmic reticulum resident protein 72) (ER protein 72) (ERp-72) (ERp72)
Gene: PDIA4

Interactor 2: LRRK2 (Q5S007)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)
Gene: LRRK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	31046837, unassigned1853
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005615 - extracellular space GO:0005783 - endoplasmic reticulum
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 645 Hs			1 2527
+	Hs
		160 A0A024R8S5_HUMAN (4-165): 4.25e-32: 132: 27.11		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		423252 PDIA1_HUMAN (4-165): 4.25e-32: 132: 27.11		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		1067725 PDIA6_HUMAN (57-283): 2.92e-31: 128: 28.51		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		671835 PDIA3_HUMAN (7-188): 4.76e-28: 120: 28.35		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		1130334 TXND5_HUMAN (547-631): 1.03e-21: 100: 34.48		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Mm
		447639 PDIA1_MOUSE (4-197): 2.74e-32: 133: 25.76		LRRK2_MOUSE (1-2527): 0: 2865: 86.09
+	Hs
		201195 PDIA4_HUMAN (1-645): 0: 571: 100.00		M3K7_HUMAN (1869-2132): 8.36e-23: 107: 28.83
+	Hs
		201178 PDIA1_HUMAN (4-165): 4.25e-32: 132: 27.11		M3K7_HUMAN (1869-2132): 8.36e-23: 107: 28.83
+	Hs
		201235 PDIA3_HUMAN (7-188): 4.76e-28: 120: 28.35		M3K7_HUMAN (1869-2132): 8.36e-23: 107: 28.83