HitPredict

Interactor 1: PDIA4 (P13667)
Protein disulfide-isomerase A4 (EC 5.3.4.1) (Endoplasmic reticulum resident protein 70) (ER protein 70) (ERp70) (Endoplasmic reticulum resident protein 72) (ER protein 72) (ERp-72) (ERp72)
Gene: PDIA4

Interactor 2: CALR3 (Q96L12)
Calreticulin-3 (Calreticulin-2) (Calsperin)
Gene: CALR3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	31056421, 34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Calreticulin~Thioredoxin_6
Common GO terms	GO:0005788 - endoplasmic reticulum lumen GO:0006457 - protein folding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 645 Hs			1 384
+	Hs
		531728 PDIA4_HUMAN (1-645): 0: 571: 100.00		CALR_HUMAN (18-348): 5e-156: 447: 51.88
+	Hs
		531729 PDIA4_HUMAN (1-645): 0: 571: 100.00		CALX_HUMAN (16-357): 7.28e-123: 368: 26.73
+	Hs
		1220455 DJC10_HUMAN (41-295): 2.22e-45: 174: 22.47		CALR3_HUMAN (1-384): 0: 543: 100.00
+	Hs
		423330 PDIA1_HUMAN (4-165): 4.25e-32: 132: 27.11		CALR3_HUMAN (1-384): 0: 543: 100.00
+	Hs
		1067796 PDIA6_HUMAN (57-283): 2.92e-31: 128: 28.51		CALR3_HUMAN (1-384): 0: 543: 100.00
+	Hs
		671897 PDIA3_HUMAN (7-188): 4.76e-28: 120: 28.35		CALR3_HUMAN (1-384): 0: 543: 100.00
+	Mm
		1322122 PDILT_MOUSE (36-522): 1.39e-28: 122: 13.06		CALR3_MOUSE (1-384): 0: 523: 82.60
+	Hs
		1240407 TXND5_HUMAN (547-631): 1.03e-21: 100: 34.48		CALR3_HUMAN (1-384): 0: 543: 100.00
+	Hs
		653650 DJC10_HUMAN (41-295): 2.22e-45: 174: 22.47		CALR_HUMAN (18-348): 5e-156: 447: 51.88
+	Hs
		653575 PDIA2_HUMAN (62-504): 2.13e-45: 171: 16.56		CALR_HUMAN (18-348): 5e-156: 447: 51.88
+	Dm
		667013 PDI_DROME (53-504): 1.95e-49: 181: 20.13		CALR_DROME (8-365): 2.58e-144: 417: 41.56
+	Hs
		653597 PDIA6_HUMAN (57-283): 2.92e-31: 128: 28.51		CALR_HUMAN (18-348): 5e-156: 447: 51.88
+	Hs
		653491 PDIA3_HUMAN (7-188): 4.76e-28: 120: 28.35		CALR_HUMAN (18-348): 5e-156: 447: 51.88
+	At
		137900 PDI21_ARATH (25-225): 1.08e-32: 131: 28.92		CALR1_ARATH (3-341): 3.11e-144: 417: 38.94
+	Hs
		654519 DJC10_HUMAN (41-295): 2.22e-45: 174: 22.47		CALX_HUMAN (16-357): 7.28e-123: 368: 26.73
+	Dm
		667020 Q3YMU0_DROME (23-164): 9.77e-23: 104: 29.75		CALR_DROME (8-365): 2.58e-144: 417: 41.56
+	Hs
		423150 PDIA1_HUMAN (4-165): 4.25e-32: 132: 27.11		CALX_HUMAN (16-357): 7.28e-123: 368: 26.73
+	Hs
		654099 PDIA3_HUMAN (7-188): 4.76e-28: 120: 28.35		CALX_HUMAN (16-357): 7.28e-123: 368: 26.73
+	Rn
		514119 PDIA3_RAT (7-188): 1.33e-26: 116: 27.84		CALX_RAT (16-357): 1.96e-122: 367: 26.97
+	Mm
		852408 PDILT_MOUSE (36-522): 1.39e-28: 122: 13.06		CLGN_MOUSE (20-336): 2.44e-111: 340: 26.28