HitPredict

Interactor 1: ONCM (P13725)
Oncostatin-M (OSM)
Gene: OSM

Interactor 2: IL6RB (P40189)
Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (CDw130) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130)
Gene: IL6ST

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.85 1.00 0.924

The method score is based on:

Property Details
Experiments 26186194, 28514442, 33961781, 8999038, 16051226
Identification Methods affinity chromatography technology, coimmunoprecipitation, anti tag coimmunoprecipitation, pull down
Interaction Type physical association, association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains IL6Ra-bind~LIF_OSM
Common GO terms GO:0002675 - positive regulation of acute inflammatory response
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0008284 - positive regulation of cell population proliferation
GO:0038165 - oncostatin-M-mediated signaling pathway
and 1 others

more...
Homologous interactions 4

Homologous interactions

Color coding for hit scores

1 252
Hs

1 918
+ Mm
+ Hs
+ Mm
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024