HitPredict

Interactor 1: PRG2 (P13727)
Bone marrow proteoglycan (BMPG) (Proteoglycan 2) [Cleaved into: Eosinophil granule major basic protein (EMBP) (MBP) (Pregnancy-associated major basic protein)]
Gene: PRG2

Interactor 2: NOTC2 (Q04721)
Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)]
Gene: NOTCH2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	EGF~Lectin_C
Common GO terms	GO:0005576 - extracellular region GO:0042742 - defense response to bacterium
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 222 Hs			1 2471
+	Hs
		980579 PRG3_HUMAN (12-222): 3.37e-54: 174: 49.30		NOTC2_HUMAN (22-2471): 0: 1386: 100.00
+	Hs
		417469 FCER2_HUMAN (5-220): 2.76e-51: 170: 20.08		NOTC2_HUMAN (22-2471): 0: 1386: 100.00
+	Hs
		532909 PRG2_HUMAN (1-222): 3.43e-57: 182: 100.00		NOTC1_HUMAN (2-1107): 2.62e-145: 509: 33.88
+	Hs
		1292818 PGCB_HUMAN (10-221): 9.83e-54: 186: 17.20		JAG2_HUMAN (2-501): 6.2e-66: 249: 33.21
+	Hs
		533110 PRG2_HUMAN (1-222): 3.43e-57: 182: 100.00		JAG2_HUMAN (2-501): 6.2e-66: 249: 33.21
+	Hs
		530367 CSPG2_HUMAN (4-221): 3.77e-46: 165: 17.00		FBN1_HUMAN (201-1638): 9.66e-69: 261: 18.41
+	Hs
		532904 PRG2_HUMAN (1-222): 3.43e-57: 182: 100.00		FBN2_HUMAN (474-1671): 8.72e-37: 155: 16.92
+	Hs
		724401 PRG3_HUMAN (12-222): 3.37e-54: 174: 49.30		FBN2_HUMAN (474-1671): 8.72e-37: 155: 16.92
+	Hs
		533105 PRG2_HUMAN (1-222): 3.43e-57: 182: 100.00		NOTC3_HUMAN (1931-2465): 6.29e-11: 70.7: 16.82