HitPredict

Interactor 1: PRG2 (P13727)
Bone marrow proteoglycan (BMPG) (Proteoglycan 2) [Cleaved into: Eosinophil granule major basic protein (EMBP) (MBP) (Pregnancy-associated major basic protein)]
Gene: PRG2

Interactor 2: PAPP1 (Q13219)
Pappalysin-1 (EC 3.4.24.79) (Insulin-like growth factor-dependent IGF-binding protein 4 protease) (IGF-dependent IGFBP-4 protease) (IGFBP-4ase) (Pregnancy-associated plasma protein A) (PAPP-A)
Gene: PAPPA

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.662

Property	Details
Experiments	10913121, 12421832, 7685339
Identification Methods	biochemical, molecular sieving, chromatography technology
Interaction Type	association, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 222 Hs			1 1627
+	Hs
		530366 CSPG2_HUMAN (4-221): 3.77e-46: 165: 17.00		LYAM3_HUMAN (1018-1605): 1.19e-48: 190: 15.03
+	Hs
		1292818 PGCB_HUMAN (10-221): 9.83e-54: 186: 17.20		JAG2_HUMAN (1066-1624): 3.02e-36: 152: 11.01
+	Hs
		533110 PRG2_HUMAN (1-222): 3.43e-57: 182: 100.00		JAG2_HUMAN (1066-1624): 3.02e-36: 152: 11.01
+	Hs
		533105 PRG2_HUMAN (1-222): 3.43e-57: 182: 100.00		NOTC3_HUMAN (1215-1627): 1.06e-20: 102: 13.29
+	Hs
		417466 FCER2_HUMAN (5-220): 2.76e-51: 170: 20.08		CR2_HUMAN (1137-1349): 9.89e-24: 111: 18.61
+	Hs
		532997 PRG2_HUMAN (1-222): 3.43e-57: 182: 100.00		FRAS1_HUMAN (1207-1607): 4.93e-16: 86.8: 14.06
+	Hs
		149947 NCAN_HUMAN (16-221): 1.24e-45: 163: 16.80		TENA_HUMAN (941-1277): 1.07e-21: 105: 12.47
+	Hs
		530363 CSPG2_HUMAN (4-221): 3.77e-46: 165: 17.00		LYAM1_HUMAN (1083-1284): 2.88e-21: 99.8: 15.35
+	Hs
		1204969 PRG3_HUMAN (12-222): 3.37e-54: 174: 49.30		FRAS1_HUMAN (1207-1607): 4.93e-16: 86.8: 14.06
+	Hs
		532932 PRG2_HUMAN (1-222): 3.43e-57: 182: 100.00		NOTC2_HUMAN (1353-1622): 5.92e-10: 66.7: 11.91
+	Hs
		532909 PRG2_HUMAN (1-222): 3.43e-57: 182: 100.00		NOTC1_HUMAN (1351-1622): 7.98e-10: 66.4: 11.93
+	Rn
		70327 G3V8R2_RAT (3-221): 2.12e-51: 180: 18.29		B2LYI9_RAT (1419-1621): 4.38e-09: 63.7: 11.65
+	Hs
		980579 PRG3_HUMAN (12-222): 3.37e-54: 174: 49.30		NOTC2_HUMAN (1353-1622): 5.92e-10: 66.7: 11.91
+	Hs
		362635 CLC4G_HUMAN (38-221): 2.03e-39: 138: 18.62		APOH_HUMAN (1344-1578): 1.71e-22: 102: 16.67
+	Hs
		417469 FCER2_HUMAN (5-220): 2.76e-51: 170: 20.08		NOTC2_HUMAN (1353-1622): 5.92e-10: 66.7: 11.91
+	Mm
		1147383 FREM1_MOUSE (31-221): 3.79e-35: 133: 17.95		FRAS1_MOUSE (1188-1607): 3.58e-15: 84.1: 12.86