HitPredict

Interactor 1: PRG2 (P13727)
Bone marrow proteoglycan (BMPG) (Proteoglycan 2) [Cleaved into: Eosinophil granule major basic protein (EMBP) (MBP) (Pregnancy-associated major basic protein)]
Gene: PRG2

Interactor 2: LAMC2 (Q13753)
Laminin subunit gamma-2 (Cell-scattering factor 140 kDa subunit) (CSF 140 kDa subunit) (Epiligrin subunit gamma) (Kalinin subunit gamma) (Kalinin/nicein/epiligrin 100 kDa subunit) (Ladsin 140 kDa subunit) (Laminin B2t chain) (Laminin-5 subunit gamma) (Large adhesive scatter factor 140 kDa subunit) (Nicein subunit gamma)
Gene: LAMC2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region GO:0008201 - heparin binding GO:0062023 - collagen-containing extracellular matrix
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 222 Hs			1 1193
+	Hs
		533105 PRG2_HUMAN (1-222): 3.43e-57: 182: 100.00		NOTC3_HUMAN (282-746): 4.73e-35: 148: 14.26
+	Hs
		532932 PRG2_HUMAN (1-222): 3.43e-57: 182: 100.00		NOTC2_HUMAN (5-590): 8.2e-31: 134: 11.32
+	Hs
		532950 PRG2_HUMAN (1-222): 3.43e-57: 182: 100.00		LAMB3_HUMAN (8-188): 2.19e-30: 132: 31.94
+	Hs
		980579 PRG3_HUMAN (12-222): 3.37e-54: 174: 49.30		NOTC2_HUMAN (5-590): 8.2e-31: 134: 11.32
+	Hs
		1045112 PRG3_HUMAN (12-222): 3.37e-54: 174: 49.30		LAMB3_HUMAN (8-188): 2.19e-30: 132: 31.94
+	Hs
		417469 FCER2_HUMAN (5-220): 2.76e-51: 170: 20.08		NOTC2_HUMAN (5-590): 8.2e-31: 134: 11.32
+	Rn
		70327 G3V8R2_RAT (3-221): 2.12e-51: 180: 18.29		B2LYI9_RAT (3-229): 8.99e-24: 111: 15.98
+	Hs
		532909 PRG2_HUMAN (1-222): 3.43e-57: 182: 100.00		NOTC1_HUMAN (5-368): 1.5e-15: 84.6: 10.23
+	Hs
		502807 PRG2_HUMAN (1-222): 3.43e-57: 182: 100.00		LAMC1_HUMAN (248-480): 1.36e-14: 81.2: 13.75
+	Hs
		172697 PGCB_HUMAN (10-221): 9.83e-54: 186: 17.20		LAMA5_HUMAN (167-420): 4.63e-12: 73.1: 11.49
+	Hs
		172640 PRG2_HUMAN (1-222): 3.43e-57: 182: 100.00		LAMA5_HUMAN (167-420): 4.63e-12: 73.1: 11.49
+	Hs
		1292818 PGCB_HUMAN (10-221): 9.83e-54: 186: 17.20		JAG2_HUMAN (418-747): 2.02e-09: 64.2: 11.59
+	Hs
		877442 PGCB_HUMAN (10-221): 9.83e-54: 186: 17.20		LAMB2_HUMAN (100-284): 2.25e-09: 64.2: 14.83
+	Hs
		532920 PRG2_HUMAN (1-222): 3.43e-57: 182: 100.00		LAMB2_HUMAN (100-284): 2.25e-09: 64.2: 14.83
+	Hs
		533110 PRG2_HUMAN (1-222): 3.43e-57: 182: 100.00		JAG2_HUMAN (418-747): 2.02e-09: 64.2: 11.59
+	Hs
		533118 PRG2_HUMAN (1-222): 3.43e-57: 182: 100.00		LAMC3_HUMAN (174-423): 3.21e-09: 63.8: 9.88
+	Hs
		532926 PRG2_HUMAN (1-222): 3.43e-57: 182: 100.00		PGBM_HUMAN (70-183): 7.52e-09: 62.7: 17.54
+	Hs
		433157 COL12_HUMAN (90-221): 3.82e-40: 147: 23.36		LAMB1_HUMAN (449-707): 5.77e-14: 79.2: 17.54