HitPredict

Interactor 1: PRG2 (P13727)
Bone marrow proteoglycan (BMPG) (Proteoglycan 2) [Cleaved into: Eosinophil granule major basic protein (EMBP) (MBP) (Pregnancy-associated major basic protein)]
Gene: PRG2

Interactor 2: FRAS1 (Q86XX4)
Extracellular matrix organizing protein FRAS1 (Fraser syndrome 1 protein)
Gene: FRAS1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0062023 - collagen-containing extracellular matrix
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 222 Hs			1 4008
+	Hs
		1204969 PRG3_HUMAN (12-222): 3.37e-54: 174: 49.30		FRAS1_HUMAN (1-4008): 0: 2806: 100.00
+	Mm
		1147383 FREM1_MOUSE (31-221): 3.79e-35: 133: 17.95		FRAS1_MOUSE (1-4008): 0: 2747: 84.84
+	Hs
		1125873 FREM1_HUMAN (4-221): 3.59e-38: 142: 18.83		FREM2_HUMAN (1296-3338): 2.12e-108: 393: 18.62
+	Hs
		532985 PRG2_HUMAN (1-222): 3.43e-57: 182: 100.00		CSPG4_HUMAN (1594-2898): 4.17e-72: 273: 17.50
+	Hs
		532935 PRG2_HUMAN (1-222): 3.43e-57: 182: 100.00		PCDH1_HUMAN (2678-3411): 7.66e-49: 194: 10.88
+	Mm
		1147382 FREM1_MOUSE (31-221): 3.79e-35: 133: 17.95		FREM2_MOUSE (1675-3140): 8.46e-60: 233: 15.44
+	Hs
		532932 PRG2_HUMAN (1-222): 3.43e-57: 182: 100.00		NOTC2_HUMAN (567-1139): 7.18e-39: 163: 13.53
+	Hs
		532909 PRG2_HUMAN (1-222): 3.43e-57: 182: 100.00		NOTC1_HUMAN (5-694): 7.39e-38: 160: 13.02
+	Hs
		980579 PRG3_HUMAN (12-222): 3.37e-54: 174: 49.30		NOTC2_HUMAN (567-1139): 7.18e-39: 163: 13.53
+	Hs
		417469 FCER2_HUMAN (5-220): 2.76e-51: 170: 20.08		NOTC2_HUMAN (567-1139): 7.18e-39: 163: 13.53
+	Hs
		533030 PRG2_HUMAN (1-222): 3.43e-57: 182: 100.00		PCSK5_HUMAN (847-1155): 3.35e-26: 121: 22.75
+	Hs
		1271407 PRG3_HUMAN (12-222): 3.37e-54: 174: 49.30		PCSK5_HUMAN (847-1155): 3.35e-26: 121: 22.75
+	Hs
		533105 PRG2_HUMAN (1-222): 3.43e-57: 182: 100.00		NOTC3_HUMAN (4-433): 4.53e-19: 98.1: 14.23
+	Hs
		532898 PRG2_HUMAN (1-222): 3.43e-57: 182: 100.00		PCSK6_HUMAN (314-564): 3.29e-18: 94.9: 20.90
+	Hs
		533067 PRG2_HUMAN (1-222): 3.43e-57: 182: 100.00		CHRD_HUMAN (90-280): 6.28e-15: 84.3: 32.11
+	Hs
		533077 PRG2_HUMAN (1-222): 3.43e-57: 182: 100.00		CELR2_HUMAN (985-1093): 1.37e-10: 70.4: 16.36
+	Hs
		533087 PRG2_HUMAN (1-222): 3.43e-57: 182: 100.00		CELR1_HUMAN (213-451): 3.32e-09: 65.8: 12.20