HitPredict

Interactor 1: PRG2 (P13727)
Bone marrow proteoglycan (BMPG) (Proteoglycan 2) [Cleaved into: Eosinophil granule major basic protein (EMBP) (MBP) (Pregnancy-associated major basic protein)]
Gene: PRG2

Interactor 2: SORL (Q92673)
Sortilin-related receptor (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (SorLA-1) (Sorting protein-related receptor containing LDLR class A repeats) (SorLA)
Gene: SORL1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	fn3~Lectin_C
Common GO terms	GO:0070062 - extracellular exosome
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 222 Hs			1 2214
+	Hs
		351043 PRG2_HUMAN (1-222): 3.43e-57: 182: 100.00		LDLR_HUMAN (1077-1278): 2.77e-29: 129: 34.48
+	Hs
		489893 CSPG2_HUMAN (4-221): 3.77e-46: 165: 17.00		PTPRF_HUMAN (1575-1852): 4.84e-34: 146: 15.66
+	Hs
		149944 NCAN_HUMAN (16-221): 1.24e-45: 163: 16.80		PTPRF_HUMAN (1575-1852): 4.84e-34: 146: 15.66
+	Hs
		351116 PRG3_HUMAN (12-222): 3.37e-54: 174: 49.30		LDLR_HUMAN (1077-1278): 2.77e-29: 129: 34.48
+	Hs
		270257 PRG2_HUMAN (1-222): 3.43e-57: 182: 100.00		LRP6_HUMAN (1445-1549): 6.8e-11: 70.1: 36.94
+	Hs
		258290 PRG2_HUMAN (1-222): 3.43e-57: 182: 100.00		LRP5_HUMAN (1445-1549): 8.69e-11: 69.7: 37.27
+	Rn
		70327 G3V8R2_RAT (3-221): 2.12e-51: 180: 18.29		B2LYI9_RAT (978-1118): 3.01e-09: 65: 15.03
+	Hs
		270349 PRG3_HUMAN (12-222): 3.37e-54: 174: 49.30		LRP6_HUMAN (1445-1549): 6.8e-11: 70.1: 36.94
+	Hs
		149947 NCAN_HUMAN (16-221): 1.24e-45: 163: 16.80		TENA_HUMAN (1661-1934): 2.12e-13: 78.5: 13.04