HitPredict

Interactor 1: PRG2 (P13727)
Bone marrow proteoglycan (BMPG) (Proteoglycan 2) [Cleaved into: Eosinophil granule major basic protein (EMBP) (MBP) (Pregnancy-associated major basic protein)]
Gene: PRG2

Interactor 2: PCSK5 (Q92824)
Proprotein convertase subtilisin/kexin type 5 (EC 3.4.21.-) (Proprotein convertase 5) (PC5) (Proprotein convertase 6) (PC6) (hPC6) (Subtilisin/kexin-like protease PC5)
Gene: PCSK5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 222 Hs			1 1860
+	Hs
		1271407 PRG3_HUMAN (12-222): 3.37e-54: 174: 49.30		PCSK5_HUMAN (1-1860): 0: 843: 100.00
+	Hs
		532959 PRG2_HUMAN (1-222): 3.43e-57: 182: 100.00		MBTP1_HUMAN (86-461): 2.5e-66: 248: 15.25
+	Hs
		533105 PRG2_HUMAN (1-222): 3.43e-57: 182: 100.00		NOTC3_HUMAN (774-1769): 3.87e-55: 215: 11.22
+	Hs
		532909 PRG2_HUMAN (1-222): 3.43e-57: 182: 100.00		NOTC1_HUMAN (1034-1739): 1.2e-38: 161: 11.49
+	Hs
		532997 PRG2_HUMAN (1-222): 3.43e-57: 182: 100.00		FRAS1_HUMAN (1239-1740): 9.56e-19: 95.9: 13.18
+	Hs
		1204969 PRG3_HUMAN (12-222): 3.37e-54: 174: 49.30		FRAS1_HUMAN (1239-1740): 9.56e-19: 95.9: 13.18
+	Hs
		149947 NCAN_HUMAN (16-221): 1.24e-45: 163: 16.80		TENA_HUMAN (560-771): 4.25e-18: 93.6: 12.15
+	Hs
		532932 PRG2_HUMAN (1-222): 3.43e-57: 182: 100.00		NOTC2_HUMAN (572-1007): 8.87e-11: 69.7: 11.79
+	Hs
		532898 PRG2_HUMAN (1-222): 3.43e-57: 182: 100.00		PCSK6_HUMAN (1207-1456): 2.95e-09: 64.3: 26.79
+	Hs
		502807 PRG2_HUMAN (1-222): 3.43e-57: 182: 100.00		LAMC1_HUMAN (590-781): 8.13e-09: 63.1: 20.30
+	Hs
		980579 PRG3_HUMAN (12-222): 3.37e-54: 174: 49.30		NOTC2_HUMAN (572-1007): 8.87e-11: 69.7: 11.79
+	Hs
		417469 FCER2_HUMAN (5-220): 2.76e-51: 170: 20.08		NOTC2_HUMAN (572-1007): 8.87e-11: 69.7: 11.79
+	Mm
		1147383 FREM1_MOUSE (31-221): 3.79e-35: 133: 17.95		FRAS1_MOUSE (1306-1762): 5.29e-15: 83.6: 13.05