HitPredict

Interactor 1: HLAE (P13747)
HLA class I histocompatibility antigen, alpha chain E (MHC class I antigen E) [Cleaved into: Soluble HLA class I histocompatibility antigen, alpha chain E (sHLA-E)]
Gene: HLA-E

Interactor 2: KLRD1 (Q13241)
Natural killer cells antigen CD94 (KP43) (Killer cell lectin-like receptor subfamily D member 1) (NK cell receptor) (CD antigen CD94)
Gene: KLRD1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	9886400, 18083576
Identification Methods	pull down, surface plasmon resonance
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	C1-set~Lectin_C, Lectin_C~MHC_I
Common GO terms	GO:0002250 - adaptive immune response GO:0005886 - plasma membrane GO:0009897 - external side of plasma membrane GO:0045953 - negative regulation of natural killer cell mediated cytotoxicity GO:0045954 - positive regulation of natural killer cell mediated cytotoxicity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 358 Hs			1 179
+	Hs
		382490 HLAA_HUMAN (1-354): 4.3e-168: 474: 78.81		CLC4D_HUMAN (2-175): 1.43e-42: 143: 19.15
+	Hs
		382561 HLAA_HUMAN (1-354): 4.3e-168: 474: 78.81		CLC4A_HUMAN (16-179): 3.06e-41: 140: 22.29
+	Hs
		382559 HLAA_HUMAN (1-354): 4.3e-168: 474: 78.81		CLC4E_HUMAN (1-176): 8.25e-41: 138: 17.02
+	Hs
		382491 HLAA_HUMAN (1-354): 4.3e-168: 474: 78.81		CLC2B_HUMAN (50-178): 1.36e-34: 120: 26.72
+	Hs
		354435 HLAB_HUMAN (1-354): 2.45e-151: 432: 77.40		KLRD1_HUMAN (1-179): 2.95e-46: 151: 100.00
+	Hs
		354602 HLAB_HUMAN (1-354): 2.45e-151: 432: 77.40		CLC4E_HUMAN (1-176): 8.25e-41: 138: 17.02
+	Hs
		488205 HLAC_HUMAN (1-354): 3.55e-146: 419: 74.65		KLRD1_HUMAN (1-179): 2.95e-46: 151: 100.00
+	Hs
		488317 HLAC_HUMAN (1-354): 3.55e-146: 419: 74.65		CLC4D_HUMAN (2-175): 1.43e-42: 143: 19.15
+	Hs
		354302 HLAB_HUMAN (1-354): 2.45e-151: 432: 77.40		NKG2A_HUMAN (10-178): 1.25e-36: 128: 31.95
+	Hs
		488421 HLAC_HUMAN (1-354): 3.55e-146: 419: 74.65		CLC4A_HUMAN (16-179): 3.06e-41: 140: 22.29
+	Hs
		488420 HLAC_HUMAN (1-354): 3.55e-146: 419: 74.65		CLC4E_HUMAN (1-176): 8.25e-41: 138: 17.02
+	Hs
		570305 HLAG_HUMAN (1-335): 7.83e-150: 427: 76.72		NKG2A_HUMAN (10-178): 1.25e-36: 128: 31.95
+	Hs
		488269 HLAC_HUMAN (1-354): 3.55e-146: 419: 74.65		CLC4G_HUMAN (2-177): 1.85e-38: 134: 21.62
+	Hs
		533125 HLAE_HUMAN (17-358): 2.88e-145: 416: 100.00		NKG2C_HUMAN (10-178): 2.93e-39: 135: 30.18
+	Hs
		533124 HLAE_HUMAN (17-358): 2.88e-145: 416: 100.00		NKG2A_HUMAN (10-178): 1.25e-36: 128: 31.95
+	Hs
		673960 HLAF_HUMAN (1-345): 2.93e-141: 406: 72.75		CL12B_HUMAN (53-176): 6.44e-39: 135: 32.06
+	Hs
		488322 HLAC_HUMAN (1-354): 3.55e-146: 419: 74.65		CLC2B_HUMAN (50-178): 1.36e-34: 120: 26.72
+	Hs
		533155 HLAE_HUMAN (17-358): 2.88e-145: 416: 100.00		CLC2B_HUMAN (50-178): 1.36e-34: 120: 26.72
+	Hs
		673971 HLAF_HUMAN (1-345): 2.93e-141: 406: 72.75		CLC2B_HUMAN (50-178): 1.36e-34: 120: 26.72
+	Hs
		570381 HLAG_HUMAN (1-335): 7.83e-150: 427: 76.72		MRC2_HUMAN (73-174): 1.04e-14: 73.1: 19.63