HitPredict

Interactor 1: KAP2 (P13861)
cAMP-dependent protein kinase type II-alpha regulatory subunit
Gene: PRKAR2A

Interactor 2: KAPCG (P22612)
cAMP-dependent protein kinase catalytic subunit gamma (PKA C-gamma) (EC 2.7.11.11)
Gene: PRKACG

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	33961781, 32707033
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pkinase~cNMP_binding, Pkinase~RIIa
Common GO terms	GO:0005829 - cytosol GO:0005952 - cAMP-dependent protein kinase complex GO:0097546 - ciliary base
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 404 Hs			1 351
+	Hs
		533780 KAP2_HUMAN (1-404): 6.63e-138: 401: 100.00		KAPCA_HUMAN (1-351): 1.79e-162: 459: 82.91
+	Hs
		533786 KAP2_HUMAN (1-404): 6.63e-138: 401: 100.00		KAPCB_HUMAN (1-351): 1.01e-160: 455: 78.63
+	Hs
		609647 KAP3_HUMAN (4-402): 1.97e-123: 365: 64.34		KAPCG_HUMAN (1-351): 6.75e-163: 460: 100.00
+	Hs
		568559 KAP3_HUMAN (4-402): 1.97e-123: 365: 64.34		KAPCA_HUMAN (1-351): 1.79e-162: 459: 82.91
+	Hs
		610686 KAP3_HUMAN (4-402): 1.97e-123: 365: 64.34		KAPCB_HUMAN (1-351): 1.01e-160: 455: 78.63
+	Mm
		397199 KAP3_MOUSE (4-402): 2.28e-121: 359: 65.13		KAPCA_MOUSE (1-351): 4.36e-161: 456: 81.48
+	Hs
		679334 KAP3_HUMAN (4-402): 1.97e-123: 365: 64.34		PRKX_HUMAN (8-351): 2.34e-143: 411: 43.35
+	Dm
		519457 KAPR2_DROME (4-401): 4.14e-105: 317: 48.12		KAPC1_DROME (1-351): 1.78e-153: 436: 74.50
+	Ce
		596863 KAPR_CAEEL (2-392): 6.23e-94: 288: 31.97		KAPC1_CAEEL (12-351): 4.82e-145: 417: 68.26
+	Sp
		736930 KAPR_SCHPO (1-394): 1.53e-81: 257: 31.50		KAPB_SCHPO (2-351): 4.52e-141: 411: 43.86
+	Hs
		217858 KAP3_HUMAN (4-402): 1.97e-123: 365: 64.34		PRKY_HUMAN (45-267): 6.93e-87: 265: 50.22
+	Ca
		1124295 KAPR_CANAL (79-388): 1.79e-64: 215: 34.19		Q5AP71_CANAL (23-351): 6.93e-141: 407: 44.31
+	Hs
		498208 KAP0_HUMAN (210-396): 6.96e-18: 86.4: 22.46		KAPCG_HUMAN (1-351): 6.75e-163: 460: 100.00
+	Hs
		498202 KAP0_HUMAN (210-396): 6.96e-18: 86.4: 22.46		KAPCA_HUMAN (1-351): 1.79e-162: 459: 82.91
+	Mm
		397222 KAP0_MOUSE (210-396): 1.26e-18: 88.7: 22.46		KAPCA_MOUSE (1-351): 4.36e-161: 456: 81.48
+	Hs
		498210 KAP0_HUMAN (210-396): 6.96e-18: 86.4: 22.46		KAPCB_HUMAN (1-351): 1.01e-160: 455: 78.63
+	Dm
		519451 KAPR1_DROME (233-396): 2.95e-19: 90.6: 25.61		KAPC1_DROME (1-351): 1.78e-153: 436: 74.50
+	Sc
		412617 KAPR_YEAST (242-389): 1.89e-19: 91.4: 22.97		KAPA_YEAST (7-351): 1.07e-145: 419: 42.53
+	Sc
		412929 KAPR_YEAST (242-389): 1.89e-19: 91.4: 22.97		KAPB_YEAST (25-351): 9.37e-145: 415: 48.18
+	Sc
		409586 KAPR_YEAST (242-389): 1.89e-19: 91.4: 22.97		KAPC_YEAST (26-351): 6.3e-141: 406: 45.29