HitPredict

Interactor 1: KAP2 (P13861)
cAMP-dependent protein kinase type II-alpha regulatory subunit
Gene: PRKAR2A

Interactor 2: KAPCB (P22694)
cAMP-dependent protein kinase catalytic subunit beta (PKA C-beta) (EC 2.7.11.11)
Gene: PRKACB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.90 1.00 0.950

The method score is based on:

Property Details
Experiments 24981860, 28514442, 33961781, 32707033, 36736316, 23455922
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation, pull down, tandem affinity purification
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Pkinase~cNMP_binding, Pkinase~RIIa
Common GO terms GO:0005813 - centrosome
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0005952 - cAMP-dependent protein kinase complex
GO:0031625 - ubiquitin protein ligase binding
and 2 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 404
Hs

1 351
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Last updated: 15 Jul 2024