HitPredict

Interactor 1: KAP2 (P13861)
cAMP-dependent protein kinase type II-alpha regulatory subunit
Gene: PRKAR2A

Interactor 2: KAP3 (P31323)
cAMP-dependent protein kinase type II-beta regulatory subunit
Gene: PRKAR2B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.85 1.00 0.927

The method score is based on:

Property Details
Experiments 24981860, 26186194, 26496610, 28514442, 33961781
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains cNMP_binding~cNMP_binding, RIIa~RIIa
Common GO terms GO:0004862 - cAMP-dependent protein kinase inhibitor activity
GO:0005737 - cytoplasm
GO:0005813 - centrosome
GO:0005829 - cytosol
GO:0005886 - plasma membrane
and 10 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 404
Hs

1 418
+ Hs
+ Sp
+ Zm
+ Ce
+ Hs
+ Hs
+ Sc
+ Ce
+ At
+ At
+ Mm
+ Mm
+ Mm
+ Hs
+ Mm
+ At
+ Dm
+ Mm
+ Bt
+ Dm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024