HitPredict

Interactor 1: EDN3 (P14138)
Endothelin-3 (ET-3) (Preproendothelin-3) (PPET3)
Gene: EDN3

Interactor 2: GAS6 (Q14393)
Growth arrest-specific protein 6 (GAS-6) (AXL receptor tyrosine kinase ligand)
Gene: GAS6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005102 - signaling receptor binding GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0007165 - signal transduction GO:0007166 - cell surface receptor signaling pathway
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 238 Hs			1 678
+	Hs
		535622 EDN3_HUMAN (1-238): 3.65e-155: 431: 100.00		NOTC1_HUMAN (8-310): 4.42e-25: 113: 17.58
+	Hs
		423070 EDN3_HUMAN (1-238): 3.65e-155: 431: 100.00		PROS_HUMAN (5-161): 1.02e-17: 89.2: 13.10
+	Hs
		535684 EDN3_HUMAN (1-238): 3.65e-155: 431: 100.00		CELR1_HUMAN (228-505): 2.11e-14: 79.5: 13.53
+	Hs
		535630 EDN3_HUMAN (1-238): 3.65e-155: 431: 100.00		NOTC2_HUMAN (4-276): 4.25e-13: 75.3: 12.30
+	Hs
		535626 EDN3_HUMAN (1-238): 3.65e-155: 431: 100.00		CNTP1_HUMAN (478-672): 7.73e-10: 64.6: 13.71