HitPredict

Interactor 1: IRF2 (P14316)
Interferon regulatory factor 2 (IRF-2)
Gene: IRF2

Interactor 2: HCFC1 (P51610)
Host cell factor 1 (HCF) (HCF-1) (C1 factor) (CFF) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6]
Gene: HCFC1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	30833792, 21903422
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006355 - regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 349 Hs			1 2035
+	Hs
		501019 IRF1_HUMAN (1-265): 1.74e-104: 311: 46.69		HCFC1_HUMAN (1-2035): 0: 643: 100.00
+	Hs
		536560 IRF2_HUMAN (1-349): 0: 511: 100.00		HCFC2_HUMAN (1593-2009): 4.41e-38: 157: 32.51
+	Hs
		501048 IRF1_HUMAN (1-265): 1.74e-104: 311: 46.69		KEAP1_HUMAN (2-262): 1.96e-59: 219: 17.11
+	Hs
		962729 IRF9_HUMAN (7-231): 1.48e-73: 234: 27.19		HCFC2_HUMAN (1593-2009): 4.41e-38: 157: 32.51