Interactor 1: IRF2 (P14316)
Interferon regulatory factor 2 (IRF-2)
Gene: IRF2

Interactor 2: MDM2 (Q00987)
E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2)
Gene: MDM2

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.70 0.60 0.649

The method score is based on:

Property Details
Experiments 19032150, 24583282
Identification Methods affinity chromatography technology, unspecified method, enzymatic study, anti tag coimmunoprecipitation, solid phase assay
Interaction Type physical association, direct interaction, ubiquitination reaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
Homologous interactions 2

Homologous interactions

Color coding for hit scores

1 349
Hs

1 491
+ Hs
+ Mm

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Last updated: 15 Jul 2024