HitPredict

Interactor 1: IRF2 (P14316)
Interferon regulatory factor 2 (IRF-2)
Gene: IRF2

Interactor 2: I2BPL (Q9H1B7)
Probable E3 ubiquitin-protein ligase IRF2BPL (EC 2.3.2.27) (Enhanced at puberty protein 1) (Interferon regulatory factor 2-binding protein-like)
Gene: IRF2BPL

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.82	0.60	0.704

Property	Details
Experiments	28514442, 30833792, 33961781, 21903422
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 349 Hs			1 796
+	Hs
		536535 IRF2_HUMAN (1-349): 0: 511: 100.00		I2BP1_HUMAN (4-209): 1.68e-19: 95.3: 38.35
+	Hs
		536533 IRF2_HUMAN (1-349): 0: 511: 100.00		I2BP2_HUMAN (9-509): 3.36e-17: 88: 20.52
+	Hs
		257600 IRF9_HUMAN (7-231): 1.48e-73: 234: 27.19		ANR17_HUMAN (62-710): 8.68e-47: 183: 11.69
+	Hs
		962712 IRF9_HUMAN (7-231): 1.48e-73: 234: 27.19		I2BP1_HUMAN (4-209): 1.68e-19: 95.3: 38.35
+	Hs
		1071055 IRF4_HUMAN (7-145): 6.44e-63: 208: 39.57		KMT2C_HUMAN (242-707): 2.59e-10: 66.8: 8.81