HitPredict

Interactor 1: HCLS1 (P14317)
Hematopoietic lineage cell-specific protein (Hematopoietic cell-specific LYN substrate 1) (LckBP1) (p75)
Gene: HCLS1

Interactor 2: ARP3 (P61158)
Actin-related protein 3 (Actin-like protein 3)
Gene: ACTR3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	12534372
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0051015 - actin filament binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 486 Hs			1 418
+	Mm
		1141103 SRC8_MOUSE (1-486): 5.07e-128: 384: 40.88		ARP3_MOUSE (1-418): 0: 588: 99.76
+	Hs
		896739 SRC8_HUMAN (1-486): 5.55e-127: 382: 39.86		ARP3_HUMAN (1-418): 0: 588: 100.00
+	Hs
		891762 SRC8_HUMAN (1-486): 5.55e-127: 382: 39.86		ACTB_HUMAN (1-414): 0: 539: 35.66
+	Hs
		929863 SRC8_HUMAN (1-486): 5.55e-127: 382: 39.86		ACTG_HUMAN (1-414): 0: 538: 35.42
+	Hs
		932154 SRC8_HUMAN (1-486): 5.55e-127: 382: 39.86		ACTC_HUMAN (3-414): 0: 527: 35.59
+	Hs
		360636 SPTA1_HUMAN (32-485): 1.43e-58: 211: 15.34		ACTS_HUMAN (3-414): 0: 528: 35.59
+	Hs
		891755 SPTN1_HUMAN (32-486): 3.87e-44: 169: 14.41		ACTB_HUMAN (1-414): 0: 539: 35.66
+	Hs
		929856 SPTN1_HUMAN (32-486): 3.87e-44: 169: 14.41		ACTG_HUMAN (1-414): 0: 538: 35.42
+	Dm
		501483 SPTCA_DROME (33-486): 1.2e-42: 164: 12.93		ACT1_DROME (3-414): 0: 534: 35.35
+	Dm
		501441 SPTCA_DROME (33-486): 1.2e-42: 164: 12.93		ACT5_DROME (3-414): 0: 533: 35.35
+	Hs
		932975 SPTN1_HUMAN (32-486): 3.87e-44: 169: 14.41		ACTS_HUMAN (3-414): 0: 528: 35.59
+	Dm
		361136 SPTCA_DROME (33-486): 1.2e-42: 164: 12.93		ACT2_DROME (3-414): 0: 532: 35.11
+	Hs
		932145 SPTN1_HUMAN (32-486): 3.87e-44: 169: 14.41		ACTC_HUMAN (3-414): 0: 527: 35.59
+	Dm
		527089 SPTCA_DROME (33-486): 1.2e-42: 164: 12.93		ACT3_DROME (3-414): 0: 531: 35.35
+	Dm
		527091 SPTCA_DROME (33-486): 1.2e-42: 164: 12.93		ACT6_DROME (3-414): 0: 530: 34.87
+	Dm
		361165 SPTCA_DROME (33-486): 1.2e-42: 164: 12.93		ACT4_DROME (3-414): 0: 526: 35.35
+	Sc
		887671 MYO5_YEAST (90-484): 5.72e-40: 156: 12.41		ACT_YEAST (1-414): 0: 528: 34.94
+	Hs
		596202 NEBU_HUMAN (145-485): 2.9e-35: 142: 16.03		ACTB_HUMAN (1-414): 0: 539: 35.66
+	Hs
		596210 NEBU_HUMAN (145-485): 2.9e-35: 142: 16.03		ACTH_HUMAN (3-414): 0: 524: 35.59
+	Sc
		811962 MYO5_YEAST (90-484): 5.72e-40: 156: 12.41		ARP3_YEAST (6-417): 1.14e-171: 489: 58.35