HitPredict

Interactor 1: TRI27 (P14373)
Zinc finger protein RFP (EC 2.3.2.27) (RING finger protein 76) (Ret finger protein) (Tripartite motif-containing protein 27)
Gene: TRIM27

Interactor 2: TBK1 (Q9UHD2)
Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1)
Gene: TBK1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.683

Property	Details
Experiments	29688809, 34646390, 16393995
Identification Methods	affinity chromatography technology, enzymatic study, in-gel kinase assay, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, phosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003676 - nucleic acid binding GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0045087 - innate immune response
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 513 Hs			1 729
+	Mm
		1143608 TRI27_MOUSE (1-513): 0: 524: 98.83		TBK1_MOUSE (1-729): 0: 558: 94.10
+	Hs
		585090 RO52_HUMAN (1-500): 2.33e-160: 465: 36.78		TBK1_HUMAN (1-729): 0: 564: 100.00
+	Hs
		536827 TRI27_HUMAN (1-513): 0: 523: 100.00		IKKE_HUMAN (1-716): 4.07e-146: 445: 48.33
+	Hs
		1318703 TRIM7_HUMAN (11-481): 1.25e-132: 396: 38.01		TBK1_HUMAN (1-729): 0: 564: 100.00
+	Hs
		158386 TRI27_HUMAN (1-513): 0: 523: 100.00		IKKB_HUMAN (9-727): 1.01e-139: 430: 18.98
+	Hs
		1354523 TRI10_HUMAN (1-480): 7.29e-125: 375: 34.36		TBK1_HUMAN (1-729): 0: 564: 100.00
+	Hs
		167459 TRI27_HUMAN (1-513): 0: 523: 100.00		IKKA_HUMAN (9-637): 4.09e-121: 381: 21.08
+	Hs
		158392 RO52_HUMAN (1-500): 2.33e-160: 465: 36.78		IKKB_HUMAN (9-727): 1.01e-139: 430: 18.98
+	Hs
		1050264 TRIM6_HUMAN (1-494): 5.87e-134: 398: 32.42		IKKE_HUMAN (1-716): 4.07e-146: 445: 48.33
+	Hs
		1050263 TRIM7_HUMAN (11-481): 1.25e-132: 396: 38.01		IKKE_HUMAN (1-716): 4.07e-146: 445: 48.33
+	Hs
		584875 RO52_HUMAN (1-500): 2.33e-160: 465: 36.78		CDK2_HUMAN (6-312): 1.71e-119: 361: 20.97
+	Hs
		167580 TRI22_HUMAN (1-494): 2.57e-131: 392: 29.12		IKKA_HUMAN (9-637): 4.09e-121: 381: 21.08
+	Hs
		1290895 TRI11_HUMAN (1-500): 9.03e-148: 433: 38.00		MARK1_HUMAN (9-407): 5.07e-87: 292: 23.33
+	Hs
		1357714 TRI35_HUMAN (3-492): 1.52e-105: 326: 25.85		MRCKB_HUMAN (6-700): 1.77e-108: 364: 16.10
+	Mm
		250797 TRI27_MOUSE (1-513): 0: 524: 98.83		ULK1_MOUSE (13-222): 5.35e-26: 116: 33.64
+	Hs
		262230 TRI27_HUMAN (1-513): 0: 523: 100.00		ULK1_HUMAN (13-222): 2.86e-26: 117: 34.10
+	Hs
		262235 RO52_HUMAN (1-500): 2.33e-160: 465: 36.78		ULK1_HUMAN (13-222): 2.86e-26: 117: 34.10
+	Hs
		1318781 TRI39_HUMAN (7-494): 3.22e-158: 462: 37.60		DCLK3_HUMAN (14-238): 2.05e-22: 104: 29.78
+	Hs
		883160 TRI68_HUMAN (1-496): 2.82e-143: 422: 34.96		HUNK_HUMAN (15-224): 1.07e-21: 102: 34.86
+	Hs
		183318 MEFV_HUMAN (17-496): 5.93e-131: 400: 37.04		ULK1_HUMAN (13-222): 2.86e-26: 117: 34.10