HitPredict

Interactor 1: TRI27 (P14373)
Zinc finger protein RFP (EC 2.3.2.27) (RING finger protein 76) (Ret finger protein) (Tripartite motif-containing protein 27)
Gene: TRIM27

Interactor 2: PIAS3 (Q9Y6X2)
E3 SUMO-protein ligase PIAS3 (EC 2.3.2.-) (E3 SUMO-protein transferase PIAS3) (Protein inhibitor of activated STAT protein 3)
Gene: PIAS3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.643

Property	Details
Experiments	31747314, 15907835
Identification Methods	affinity chromatography technology, enzymatic study, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0008270 - zinc ion binding GO:0016925 - protein sumoylation and 1 others more... GO:0019789 - SUMO transferase activity
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 513 Hs			1 628
+	Hs
		277914 TRI27_HUMAN (1-513): 0: 523: 100.00		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		278217 TRI27_HUMAN (1-513): 0: 523: 100.00		PIAS2_HUMAN (1-550): 0: 651: 59.00
+	Hs
		278162 TRIM5_HUMAN (1-494): 9.4e-127: 380: 29.15		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		278189 TRI35_HUMAN (3-492): 1.52e-105: 326: 25.85		PIAS1_HUMAN (1-628): 0: 728: 56.69
+	Hs
		536921 TRI27_HUMAN (1-513): 0: 523: 100.00		PIAS4_HUMAN (2-477): 2.11e-177: 514: 46.71
+	Hs
		278302 TRI50_HUMAN (1-488): 4.24e-121: 365: 27.53		PIAS2_HUMAN (1-550): 0: 651: 59.00
+	Hs
		135032 TRI38_HUMAN (1-494): 7.99e-134: 397: 32.40		PIAS4_HUMAN (2-477): 2.11e-177: 514: 46.71