HitPredict

Interactor 1: DRD2 (P14416)
D(2) dopamine receptor (Dopamine D2 receptor)
Gene: DRD2

Interactor 2: FLNA (P21333)
Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)
Gene: FLNA

Species: Homo sapiens

Source: dip

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	12181426, 11320256
Identification Methods	affinity chromatography technology, coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007195 - adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:0015459 - potassium channel regulator activity GO:0043204 - perikaryon GO:0051209 - release of sequestered calcium ion into cytosol and 1 others more... GO:0098978 - glutamatergic synapse
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 443 Hs			1 2647
+	Hs
		597984 DRD3_HUMAN (8-443): 9.85e-70: 228: 46.03		FLNA_HUMAN (1-2647): 0: 2776: 100.00
+	Hs
		428914 ADRB2_HUMAN (322-442): 1.41e-27: 115: 35.54		FLNA_HUMAN (1-2647): 0: 2776: 100.00
+	Hs
		597983 OPRM_HUMAN (353-441): 3.2e-09: 60.5: 26.09		FLNA_HUMAN (1-2647): 0: 2776: 100.00
+	Hs
		723009 ADA1B_HUMAN (320-443): 2.16e-29: 122: 33.86		FLNC_HUMAN (32-2647): 0: 1432: 35.96
+	Hs
		722936 ADA1A_HUMAN (323-442): 2.29e-27: 115: 32.80		FLNC_HUMAN (32-2647): 0: 1432: 35.96
+	Hs
		626688 ADA1D_HUMAN (346-437): 8.65e-27: 114: 40.86		FLNC_HUMAN (32-2647): 0: 1432: 35.96
+	Hs
		656944 5HT1B_HUMAN (350-441): 6.17e-19: 90.1: 45.75		ACTN2_HUMAN (6-459): 1.76e-121: 410: 23.62