HitPredict

Interactor 1: DRD2 (P14416)
D(2) dopamine receptor (Dopamine D2 receptor)
Gene: DRD2

Interactor 2: NEB2 (Q96SB3)
Neurabin-2 (Neurabin-II) (Protein phosphatase 1 regulatory subunit 9B) (Spinophilin)
Gene: PPP1R9B

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.61	0.60	0.606

Property	Details
Experiments	10391935, 17464283
Identification Methods	two hybrid, pull down
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001975 - response to amphetamine GO:0005886 - plasma membrane GO:0030425 - dendrite GO:0035094 - response to nicotine
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 443 Hs			1 817
+	Rn
		192518 DRD2_RAT (1-443): 2.33e-107: 326: 95.72		NEB2_RAT (1-817): 2.3e-118: 379: 95.23
+	Hs
		591244 ACM3_HUMAN (3-443): 2.79e-84: 271: 20.53		NEB2_HUMAN (1-817): 3.09e-122: 389: 100.00
+	Hs
		445808 ADA2A_HUMAN (2-442): 2.38e-77: 250: 31.11		NEB2_HUMAN (1-817): 3.09e-122: 389: 100.00
+	Hs
		574790 ADA2B_HUMAN (43-442): 1.12e-74: 242: 29.31		NEB2_HUMAN (1-817): 3.09e-122: 389: 100.00
+	Hs
		578814 ADA2C_HUMAN (43-441): 9.86e-66: 219: 30.30		NEB2_HUMAN (1-817): 3.09e-122: 389: 100.00
+	Hs
		723011 ADA1B_HUMAN (320-443): 2.16e-29: 122: 33.86		NEB2_HUMAN (1-817): 3.09e-122: 389: 100.00
+	Mm
		897201 DRD2_MOUSE (1-443): 1.92e-107: 326: 95.50		DLG4_MOUSE (438-714): 8.12e-28: 122: 16.38
+	Ce
		101928 O17470_CAEEL (3-443): 9.27e-68: 230: 26.21		G1K0W3_CAEEL (464-756): 6.98e-18: 90.8: 13.59
+	Hs
		280028 DRD3_HUMAN (8-443): 9.85e-70: 228: 46.03		MPDZ_HUMAN (26-762): 3.82e-18: 92: 11.71
+	Hs
		626691 ADA1D_HUMAN (346-437): 8.65e-27: 114: 40.86		LNX1_HUMAN (273-773): 3.79e-34: 142: 13.78
+	Rn
		495779 ADRB2_RAT (323-442): 1.27e-28: 118: 36.67		DLG4_RAT (438-714): 1e-27: 121: 16.38
+	Mm
		830268 SSR4_MOUSE (232-442): 4.91e-21: 96.3: 17.93		DLG2_MOUSE (419-621): 1.35e-28: 125: 21.18
+	Mm
		830267 SSR4_MOUSE (232-442): 4.91e-21: 96.3: 17.93		DLG4_MOUSE (438-714): 8.12e-28: 122: 16.38
+	Rn
		677498 SSR4_RAT (232-442): 3.47e-20: 93.6: 17.93		DLG4_RAT (438-714): 1e-27: 121: 16.38
+	Hs
		626682 ADA1D_HUMAN (346-437): 8.65e-27: 114: 40.86		DLG1_HUMAN (435-691): 6e-19: 94.1: 15.04
+	Mm
		676818 SSR2_MOUSE (232-442): 1.5e-16: 82.8: 16.82		DLG4_MOUSE (438-714): 8.12e-28: 122: 16.38
+	Hs
		428993 ADRB2_HUMAN (322-442): 1.41e-27: 115: 35.54		SYJ2B_HUMAN (496-589): 9.27e-18: 82.7: 27.66
+	Hs
		626687 ADA1D_HUMAN (346-437): 8.65e-27: 114: 40.86		SCRIB_HUMAN (412-596): 5.32e-14: 78.7: 21.15
+	Mm
		578603 ADRB2_MOUSE (323-442): 6.07e-29: 119: 37.50		MAGI3_MOUSE (408-665): 1.03e-10: 67.7: 14.62
+	Hs
		429068 ADRB2_HUMAN (322-442): 1.41e-27: 115: 35.54		MAGI3_HUMAN (223-665): 2.08e-11: 70: 11.91