HitPredict

Interactor 1: NCF1 (P14598)
Neutrophil cytosol factor 1 (NCF-1) (47 kDa autosomal chronic granulomatous disease protein) (47 kDa neutrophil oxidase factor) (NCF-47K) (Neutrophil NADPH oxidase factor 1) (Nox organizer 2) (Nox-organizing protein 2) (SH3 and PX domain-containing protein 1A) (p47-phox)
Gene: NCF1

Interactor 2: NCF2 (P19878)
Neutrophil cytosol factor 2 (NCF-2) (67 kDa neutrophil oxidase factor) (NADPH oxidase activator 2) (Neutrophil NADPH oxidase factor 2) (p67-phox)
Gene: NCF2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.986

The method score is based on:

Property Details
Experiments 32296183, 11796733, 12169629, 8550629, 36163178, 16782902, 7938008, 10486263, 11733522, 16052631, 8676437, 8760383, unassigned1304, 16297854, 15657040, 19129478
Identification Methods two hybrid, pull down, affinity chromatography technology, far western blotting, unspecified method, x-ray crystallography, two hybrid prey pooling approach, two hybrid array, validated two hybrid, anti bait coimmunoprecipitation and 3 others

more...
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains NECFESHC~SH3_1, SH3_1~p47_phox_C, PB1~SH3_1, SH3_1~SH3_1
Common GO terms GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0006801 - superoxide metabolic process
GO:0006968 - cellular defense response
GO:0009055 - electron transfer activity
and 8 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 390
Hs

1 526
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Rn

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024