HitPredict

Interactor 1: NCF1 (P14598)
Neutrophil cytosol factor 1 (NCF-1) (47 kDa autosomal chronic granulomatous disease protein) (47 kDa neutrophil oxidase factor) (NCF-47K) (Neutrophil NADPH oxidase factor 1) (Nox organizer 2) (Nox-organizing protein 2) (SH3 and PX domain-containing protein 1A) (p47-phox)
Gene: NCF1

Interactor 2: ADAM8 (P78325)
Disintegrin and metalloproteinase domain-containing protein 8 (ADAM 8) (EC 3.4.24.-) (Cell surface antigen MS2) (CD antigen CD156a)
Gene: ADAM8

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	25825872
Identification Methods	phage display, peptide array
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0032010 - phagolysosome GO:0051897 - positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 390 Hs			1 824
+	Hs
		537641 NCF1_HUMAN (1-390): 1.2e-102: 310: 100.00		ADAM9_HUMAN (24-723): 4.42e-157: 480: 30.77
+	Hs
		537670 NCF1_HUMAN (1-390): 1.2e-102: 310: 100.00		ADA19_HUMAN (28-824): 2.25e-144: 451: 33.07
+	Hs
		537642 NCF1_HUMAN (1-390): 1.2e-102: 310: 100.00		ADA15_HUMAN (22-808): 1.19e-124: 397: 30.82
+	Hs
		1034723 SH3G2_HUMAN (6-211): 5.16e-32: 125: 10.68		ADAM9_HUMAN (24-723): 4.42e-157: 480: 30.77
+	Hs
		557788 NCK1_HUMAN (130-350): 9.29e-34: 131: 17.16		ADA19_HUMAN (28-824): 2.25e-144: 451: 33.07
+	Hs
		1307433 SH3G2_HUMAN (6-211): 5.16e-32: 125: 10.68		ADA19_HUMAN (28-824): 2.25e-144: 451: 33.07
+	Hs
		298977 SRBS2_HUMAN (163-283): 1.9e-20: 95.7: 21.15		ADAM9_HUMAN (24-723): 4.42e-157: 480: 30.77
+	Hs
		197624 ITSN2_HUMAN (8-390): 2.54e-15: 80.2: 11.00		ADA12_HUMAN (23-824): 7.76e-150: 464: 34.24
+	Hs
		197604 SH319_HUMAN (81-282): 8.99e-15: 77.9: 17.83		ADA12_HUMAN (23-824): 7.76e-150: 464: 34.24
+	Hs
		557680 NCK1_HUMAN (130-350): 9.29e-34: 131: 17.16		ADA15_HUMAN (22-808): 1.19e-124: 397: 30.82
+	Hs
		1034770 SH3G2_HUMAN (6-211): 5.16e-32: 125: 10.68		ADA15_HUMAN (22-808): 1.19e-124: 397: 30.82
+	Hs
		298978 SRBS2_HUMAN (163-283): 1.9e-20: 95.7: 21.15		ADA15_HUMAN (22-808): 1.19e-124: 397: 30.82
+	Hs
		1034763 SH3R3_HUMAN (5-388): 1.87e-16: 83.2: 13.76		ADA15_HUMAN (22-808): 1.19e-124: 397: 30.82
+	Ce
		106478 Q19901_CAEEL (3-282): 5.41e-36: 141: 12.75		ADM2_CAEEL (34-790): 6.24e-101: 336: 25.34
+	Hs
		152245 NCF1_HUMAN (1-390): 1.2e-102: 310: 100.00		ADA10_HUMAN (63-508): 1.87e-23: 108: 24.91
+	Hs
		152280 MYO1E_HUMAN (3-283): 4.56e-53: 191: 15.20		ADA10_HUMAN (63-508): 1.87e-23: 108: 24.91
+	Hs
		152249 NCK1_HUMAN (130-350): 9.29e-34: 131: 17.16		ADA10_HUMAN (63-508): 1.87e-23: 108: 24.91
+	Hs
		152325 SH3G3_HUMAN (222-285): 2.65e-18: 87.1: 12.50		ADA10_HUMAN (63-508): 1.87e-23: 108: 24.91
+	Hs
		152297 SH319_HUMAN (81-282): 8.99e-15: 77.9: 17.83		ADA10_HUMAN (63-508): 1.87e-23: 108: 24.91
+	Hs
		152209 VINEX_HUMAN (85-388): 1.86e-14: 77: 12.95		ADA10_HUMAN (63-508): 1.87e-23: 108: 24.91