HitPredict

Interactor 1: NCF1 (P14598)
Neutrophil cytosol factor 1 (NCF-1) (47 kDa autosomal chronic granulomatous disease protein) (47 kDa neutrophil oxidase factor) (NCF-47K) (Neutrophil NADPH oxidase factor 1) (Nox organizer 2) (Nox-organizing protein 2) (SH3 and PX domain-containing protein 1A) (p47-phox)
Gene: NCF1

Interactor 2: PAK1 (Q13153)
Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (Alpha-PAK) (p21-activated kinase 1) (PAK-1) (p65-PAK)
Gene: PAK1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.651

Property	Details
Experiments	7618083, 16099876, 12855698
Identification Methods	protein kinase assay, anti tag coimmunoprecipitation
Interaction Type	phosphorylation reaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0030425 - dendrite
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 390 Hs			1 545
+	Hs
		537603 NCF1_HUMAN (1-390): 1.2e-102: 310: 100.00		AKT1_HUMAN (145-544): 8.19e-134: 399: 21.71
+	Hs
		1026163 SRC8_HUMAN (4-282): 7.5e-33: 131: 12.67		PAK1_HUMAN (1-545): 0: 558: 100.00
+	Hs
		557676 NCK1_HUMAN (130-350): 9.29e-34: 131: 17.16		PAK1_HUMAN (1-545): 0: 558: 100.00
+	Mm
		292046 NCK1_MOUSE (130-350): 2.3e-33: 129: 17.16		PAK1_MOUSE (1-545): 0: 552: 97.62
+	Hs
		209044 NCK2_HUMAN (161-327): 3.03e-19: 90.2: 14.98		PAK1_HUMAN (1-545): 0: 558: 100.00
+	Hs
		1026907 SRC8_HUMAN (4-282): 7.5e-33: 131: 12.67		PAK2_HUMAN (1-544): 2.14e-168: 489: 74.82
+	Hs
		557677 NCK1_HUMAN (130-350): 9.29e-34: 131: 17.16		PAK2_HUMAN (1-544): 2.14e-168: 489: 74.82
+	Hs
		277595 NCK1_HUMAN (130-350): 9.29e-34: 131: 17.16		PAK3_HUMAN (1-544): 2.48e-167: 487: 77.03
+	Hs
		298975 SRBS2_HUMAN (163-283): 1.9e-20: 95.7: 21.15		PAK2_HUMAN (1-544): 2.14e-168: 489: 74.82
+	Hs
		209045 NCK2_HUMAN (161-327): 3.03e-19: 90.2: 14.98		PAK2_HUMAN (1-544): 2.14e-168: 489: 74.82
+	Hs
		1026931 SH3R3_HUMAN (5-388): 1.87e-16: 83.2: 13.76		PAK2_HUMAN (1-544): 2.14e-168: 489: 74.82
+	Hs
		235500 VINEX_HUMAN (85-388): 1.86e-14: 77: 12.95		PAK2_HUMAN (1-544): 2.14e-168: 489: 74.82
+	Hs
		277606 ITSN1_HUMAN (54-227): 2.01e-11: 67.7: 12.16		PAK3_HUMAN (1-544): 2.48e-167: 487: 77.03
+	Ce
		1089181 Q95PW9_CAEEL (121-281): 2.2e-18: 87.9: 20.73		PK1_CAEEL (10-543): 2.19e-143: 427: 52.03
+	Hs
		298951 SRBS2_HUMAN (163-283): 1.9e-20: 95.7: 21.15		AKT2_HUMAN (141-544): 1.54e-138: 411: 22.52
+	Hs
		1052339 SRC8_HUMAN (4-282): 7.5e-33: 131: 12.67		STK26_HUMAN (262-545): 3.56e-122: 367: 43.71
+	Hs
		235479 VINEX_HUMAN (85-388): 1.86e-14: 77: 12.95		AKT2_HUMAN (141-544): 1.54e-138: 411: 22.52
+	Hs
		235471 VINEX_HUMAN (85-388): 1.86e-14: 77: 12.95		KAPCA_HUMAN (228-544): 8.55e-131: 386: 23.62
+	Dm
		1214366 NCK_DROME (88-376): 3.85e-35: 137: 18.98		PAK_DROME (9-144): 1.07e-27: 119: 48.34
+	Hs
		235609 VINEX_HUMAN (85-388): 1.86e-14: 77: 12.95		PAK5_HUMAN (68-180): 2.09e-13: 74.9: 26.09