HitPredict

Interactor 1: NCF1 (P14598)
Neutrophil cytosol factor 1 (NCF-1) (47 kDa autosomal chronic granulomatous disease protein) (47 kDa neutrophil oxidase factor) (NCF-47K) (Neutrophil NADPH oxidase factor 1) (Nox organizer 2) (Nox-organizing protein 2) (SH3 and PX domain-containing protein 1A) (p47-phox)
Gene: NCF1

Interactor 2: ADA15 (Q13444)
Disintegrin and metalloproteinase domain-containing protein 15 (ADAM 15) (EC 3.4.24.-) (Metalloprotease RGD disintegrin protein) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15) (MDC-15) (Metargidin)
Gene: ADAM15

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	25825872
Identification Methods	phage display
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0017124 - SH3 domain binding GO:0045087 - innate immune response
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 390 Hs			1 863
+	Hs
		537641 NCF1_HUMAN (1-390): 1.2e-102: 310: 100.00		ADAM9_HUMAN (31-823): 4.3e-168: 510: 31.00
+	Hs
		537670 NCF1_HUMAN (1-390): 1.2e-102: 310: 100.00		ADA19_HUMAN (8-859): 3.95e-164: 504: 33.00
+	Hs
		537623 NCF1_HUMAN (1-390): 1.2e-102: 310: 100.00		ADAM8_HUMAN (1-851): 5.57e-160: 489: 31.26
+	Hs
		557680 NCK1_HUMAN (130-350): 9.29e-34: 131: 17.16		ADA15_HUMAN (1-863): 0: 556: 100.00
+	Hs
		1034770 SH3G2_HUMAN (6-211): 5.16e-32: 125: 10.68		ADA15_HUMAN (1-863): 0: 556: 100.00
+	Hs
		298978 SRBS2_HUMAN (163-283): 1.9e-20: 95.7: 21.15		ADA15_HUMAN (1-863): 0: 556: 100.00
+	Hs
		1034763 SH3R3_HUMAN (5-388): 1.87e-16: 83.2: 13.76		ADA15_HUMAN (1-863): 0: 556: 100.00
+	Hs
		1034723 SH3G2_HUMAN (6-211): 5.16e-32: 125: 10.68		ADAM9_HUMAN (31-823): 4.3e-168: 510: 31.00
+	Hs
		557788 NCK1_HUMAN (130-350): 9.29e-34: 131: 17.16		ADA19_HUMAN (8-859): 3.95e-164: 504: 33.00
+	Hs
		1307433 SH3G2_HUMAN (6-211): 5.16e-32: 125: 10.68		ADA19_HUMAN (8-859): 3.95e-164: 504: 33.00
+	Hs
		152245 NCF1_HUMAN (1-390): 1.2e-102: 310: 100.00		ADA10_HUMAN (69-525): 5.98e-94: 313: 23.44
+	Hs
		298977 SRBS2_HUMAN (163-283): 1.9e-20: 95.7: 21.15		ADAM9_HUMAN (31-823): 4.3e-168: 510: 31.00
+	Hs
		197624 ITSN2_HUMAN (8-390): 2.54e-15: 80.2: 11.00		ADA12_HUMAN (42-856): 8.46e-167: 509: 35.32
+	Hs
		197604 SH319_HUMAN (81-282): 8.99e-15: 77.9: 17.83		ADA12_HUMAN (42-856): 8.46e-167: 509: 35.32
+	Ce
		106478 Q19901_CAEEL (3-282): 5.41e-36: 141: 12.75		ADM2_CAEEL (43-862): 2.65e-112: 368: 23.60
+	Hs
		152280 MYO1E_HUMAN (3-283): 4.56e-53: 191: 15.20		ADA10_HUMAN (69-525): 5.98e-94: 313: 23.44
+	Hs
		152249 NCK1_HUMAN (130-350): 9.29e-34: 131: 17.16		ADA10_HUMAN (69-525): 5.98e-94: 313: 23.44
+	Hs
		152325 SH3G3_HUMAN (222-285): 2.65e-18: 87.1: 12.50		ADA10_HUMAN (69-525): 5.98e-94: 313: 23.44
+	Hs
		152297 SH319_HUMAN (81-282): 8.99e-15: 77.9: 17.83		ADA10_HUMAN (69-525): 5.98e-94: 313: 23.44
+	Hs
		152209 VINEX_HUMAN (85-388): 1.86e-14: 77: 12.95		ADA10_HUMAN (69-525): 5.98e-94: 313: 23.44