HitPredict

Interactor 1: NCF1 (P14598)
Neutrophil cytosol factor 1 (NCF-1) (47 kDa autosomal chronic granulomatous disease protein) (47 kDa neutrophil oxidase factor) (NCF-47K) (Neutrophil NADPH oxidase factor 1) (Nox organizer 2) (Nox-organizing protein 2) (SH3 and PX domain-containing protein 1A) (p47-phox)
Gene: NCF1

Interactor 2: ABI1 (Q8IZP0)
Abl interactor 1 (Abelson interactor 1) (Abi-1) (Abl-binding protein 4) (AblBP4) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Nap1-binding protein) (Nap1BP) (Spectrin SH3 domain-binding protein 1) (e3B1)
Gene: ABI1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.46	1.00	0.683

Property	Details
Experiments	12681507
Identification Methods	two hybrid, pull down, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	NECFESHC~SH3_1, SH3_1~p47_phox_C, SH3_1~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0017124 - SH3 domain binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 390 Hs			1 508
+	Mm
		997647 NCF1_MOUSE (1-390): 5.31e-98: 298: 81.84		ABI1_MOUSE (1-508): 1.42e-122: 369: 91.93
+	Hs
		1052249 SRC8_HUMAN (4-282): 7.5e-33: 131: 12.67		ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00
+	Hs
		557737 NCK1_HUMAN (130-350): 9.29e-34: 131: 17.16		ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00
+	Hs
		537645 NCF1_HUMAN (1-390): 1.2e-102: 310: 100.00		SRC8_HUMAN (291-502): 1.23e-34: 138: 20.72
+	Hs
		537593 NCF1_HUMAN (1-390): 1.2e-102: 310: 100.00		NCF2_HUMAN (211-501): 2.81e-27: 117: 12.29
+	Hs
		557806 NCK1_HUMAN (130-350): 9.29e-34: 131: 17.16		ABI2_HUMAN (1-508): 1.41e-81: 264: 59.84
+	Hs
		537657 NCF1_HUMAN (1-390): 1.2e-102: 310: 100.00		SH3R1_HUMAN (244-503): 3.15e-09: 61.6: 17.28
+	Hs
		203224 MYO1E_HUMAN (3-283): 4.56e-53: 191: 15.20		SYNJ1_HUMAN (38-463): 1.36e-41: 161: 11.55
+	Hs
		203208 NCK1_HUMAN (130-350): 9.29e-34: 131: 17.16		SYNJ1_HUMAN (38-463): 1.36e-41: 161: 11.55
+	Hs
		203249 SH3G2_HUMAN (6-211): 5.16e-32: 125: 10.68		SYNJ1_HUMAN (38-463): 1.36e-41: 161: 11.55
+	Hs
		1052195 SRC8_HUMAN (4-282): 7.5e-33: 131: 12.67		SRC8_HUMAN (291-502): 1.23e-34: 138: 20.72
+	Hs
		1052345 SRC8_HUMAN (4-282): 7.5e-33: 131: 12.67		ASAP1_HUMAN (107-505): 8.23e-33: 135: 16.83
+	Hs
		557823 NCK1_HUMAN (130-350): 9.29e-34: 131: 17.16		ASAP1_HUMAN (107-505): 8.23e-33: 135: 16.83
+	Hs
		1307440 SH3G2_HUMAN (6-211): 5.16e-32: 125: 10.68		ASAP1_HUMAN (107-505): 8.23e-33: 135: 16.83
+	Rn
		71363 B2RZ33_RAT (130-350): 1.82e-33: 130: 17.16		SRC8_RAT (291-502): 1.57e-31: 129: 19.73
+	Hs
		166030 NCK1_HUMAN (130-350): 9.29e-34: 131: 17.16		SYNJ2_HUMAN (39-458): 2.1e-26: 115: 13.88
+	Hs
		235470 NCK1_HUMAN (130-350): 9.29e-34: 131: 17.16		VINEX_HUMAN (229-504): 5.02e-15: 79.8: 15.58
+	Hs
		1052363 SRC8_HUMAN (4-282): 7.5e-33: 131: 12.67		CD2AP_HUMAN (451-508): 2.26e-14: 77.9: 40.68
+	Hs
		1307444 SH3G2_HUMAN (6-211): 5.16e-32: 125: 10.68		CD2AP_HUMAN (451-508): 2.26e-14: 77.9: 40.68
+	Hs
		1078900 SH3G2_HUMAN (6-211): 5.16e-32: 125: 10.68		ITSN1_HUMAN (399-504): 1.82e-09: 62.5: 20.35